Pinerolo

The trial investigates the outcomes of Complete Mesocolic Excision with Central Vascular Ligation (CME+CVL) compared to standard right hemicolectomy without CME in patients with stage II to IV right or proximal transverse colon cancer. The purpose is to evaluate disease-free survival as the primary outcome, along with safety, cancer-related results, surgical quality, and quality of life as secondary outcomes. This is a randomized controlled trial conducted in Italy involving adult patients with right colon cancer who require surgery. Patients will be randomly assigned in equal numbers to either the CME+CVL surgery group or the standard non-CME right colectomy group. The CME+CVL surgery involves precise removal of lymphovascular tissue and vessels at their origins while preserving intact mesocolon coverage. The standard surgery involves vessel transection near the superior mesenteric vessels without extensive clearing. Surgical approaches can be open, laparoscopic, or robotic, with choices about anastomosis and drain placement left to the surgeon. Participants will be followed for a total of five years after surgery, with evaluations at 1, 4, 12, 24, 36, and 60 months. Data collected will include demographic information, perioperative and postoperative characteristics, oncologic outcomes, safety measures, and quality of life assessments. The primary outcome measured is disease-free survival at three years. The study plans to recruit 416 patients over one and a half years and continue follow-up for five years, totaling about six and a half years of study duration.

Researchers are conducting a study to continuously evaluate the quality of healthcare provided in semi-intensive care units. The goal is to develop indicators that measure healthcare quality based on data collected from patients in these units and the structural characteristics of the hospitals. This evaluation aims to identify areas of care that need improvement for different types of patients. The study will collect and analyze data over a period of five years. Each year, a report will be produced to show the results and quality levels of care in each semi-intensive care unit. This ongoing monitoring will help assess the care provided and guide improvements. Participants in the study are patients hospitalized in semi-intensive care units. Data related to patient care and hospital structures will be gathered and used to create quality indicators. The outcomes measured include healthcare quality for various patient risk groups, with continuous evaluation from January 2021 through December 2025. Annual reports will track the progress and effectiveness of care in these units.