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Researchers are evaluating a method to improve Cardiac Resynchronization Therapy CRT implantation by using a cloud-based pre-procedural roadmap. This roadmap integrates 3D images from electrical activation sequences and coronary venous anatomy obtained by non-invasive tests. The study aims to see if this approach can guide the placement of the left ventricular lead to areas of delayed electrical activation and reduce the hearts left ventricular end-systolic volume by at least 15% in 75% of patients six months after treatment. Participants will undergo CRT implantation guided by XSpline technology, which uses patient data including ECG, echocardiography, and computed tomography angiography. The imaging data are processed on a cloud platform to identify the best site for lead placement. The procedure follows local protocols with visual verification by X-ray to confirm lead position. The study includes at least 150 patients and compares the new approachs outcomes to previous CRT populations. During the study, participants will have their clinical and cardiovascular history recorded along with routine examinations and imaging tests. Researchers will monitor heart function changes, procedural time, and total X-ray exposure over six months. The main outcome measured is the reduction in left ventricular end-systolic volume. Safety and feasibility of the XSpline platform use for CRT implantation will also be assessed.

Researchers are evaluating the EuroHeart program, an observational and prospective multicenter initiative designed to improve quality of care for patients with common cardiovascular diseases such as Acute Coronary Syndrome ACS, heart failure, and atrial fibrillation. EuroHeart collects standardized and harmonized patient data to support continuous quality improvement by monitoring adherence to quality indicators defined by the European Society of Cardiology ESC. The program aims to understand how well proven treatments are applied in everyday clinical practice. The study involves continuous data collection from consecutive patients hospitalized or treated for these cardiovascular conditions. Participants enter a 12-month follow-up period during which clinical events and health status data are gathered. This registry specifically evaluates adherence to ESC quality indicators in Italian clinical practice, including measures such as time to reperfusion and prescription of recommended medications at discharge. Participants will be monitored through regular collection of clinical data over the 12 months following enrollment. Researchers will assess adherence to multiple ESC quality indicators related to treatment and management of STEMI and NSTEMI patients, including evaluations of left ventricular function, lipid levels, and use of dual antiplatelet therapy and other medications. The study also tracks cardiovascular and non-cardiovascular events during follow-up to support quality improvement efforts. Participation involves consent and data collection without experimental treatments.

Researchers are evaluating an individualized tablet-based cognitive training program designed to improve executive functions such as planning, cognitive flexibility, and problem solving in healthy older adults aged 65 to 75 years. The study aims to enhance cognitive performance and compares two delivery methods self-administered training at home versus supervised sessions with a trained researcher. This trial is randomized and parallel in design with no masking, focusing on cognitive enhancement and prevention of decline. Participants are randomly assigned to either a home-based group, where they perform training independently using a tablet application, or a supervised group, where training is conducted in person under researcher supervision. Each group completes two 1-hour training sessions per week for 4 consecutive weeks. Both groups engage in the same individualized tablet-based exercises targeting executive functions. Throughout the study, cognitive assessments are conducted at baseline, immediately after the 4-week intervention, and at a 3-month follow-up to evaluate changes in executive and global cognitive functioning. The primary outcome measures include standardized neuropsychological tests such as the Tower of London Test and the Frontal Assessment Battery. Researchers monitor cognitive performance changes over time to assess the effectiveness and maintenance of the training effects.

Autism Spectrum Disorder ASD is a complex condition marked by challenges in social communication and repetitive behaviors, often accompanied by various physical, mental, and developmental issues. Early signs usually appear in the first year of life, including reduced social attention and unusual object use. Early interventions for infants showing these signs may improve development, reduce symptoms, and lessen caregiver stress. This research aims to assess FIRRST, a parent-led telehealth intervention, in a randomized trial with 132 infants aged 9 to 14 months showing early ASD signs, to improve developmental and brain outcomes compared to parent education alone. The study compares two groups one receiving FIRRST, which is based on natural developmental behavioral principles targeting early ASD signs and motor skills through parent involvement and tailored activities, delivered by trained professionals via telehealth and a control group receiving written educational materials and monthly counseling to support family well-being. The intervention lasts 24 weeks, followed by a 24-week follow-up period after the intervention ends. Participants will undergo assessments at three points baseline, after 24 weeks of intervention, and 24 weeks post-intervention. Evaluations include infant development, ASD symptoms, brain activity through EEG, parent mental health, and parent-child interactions. The trial monitors changes over a year to understand the effects of early telehealth intervention on infants at risk for ASD and their families.