Varapodio

Researchers are studying the long-term effects of two dietary interventions, the fasting mimicking diet FMD and the Longevity Diet LD, on body composition and cardiovascular biomarkers in adults aged 30 to 65. This large randomized, open-label trial builds on earlier studies showing short-term benefits of these diets on body weight, BMI, and cardiovascular health, aiming to understand their impact over a longer period. Participants are divided into groups, including one following the FMD with a 5-day meal program every three months for one year, and another group that previously completed FMD cycles continuing the FMD plan for an additional year. The FMD involves consuming a plant-based nutrient meal replacement for five consecutive days. Participants receive the FMD boxes and ketone test strips to self-monitor during the diet cycles. Throughout the study, participants undergo body composition assessments using bioelectrical impedance analysis, measurements of height, weight, vital signs, and laboratory blood tests at baseline and follow-up visits after three and five FMD cycles. Researchers monitor adherence, safety, and changes in fat mass, cardiovascular risk factors, and medication use. The study aims to evaluate the maintenance of fat mass loss and risk factor improvements over one year of follow-up.