Chokwe

Researchers are investigating whether incomplete control of HIV infection despite antiretroviral treatment could lead to the virus developing resistance mutations that make managing HIV more difficult. This study focuses on patients living with HIV in Mozambique who are receiving treatment but still have detectable levels of the virus. The goal is to understand if resistance to key drugs like dolutegravir, tenofovir, and lamivudine is emerging in this group. The study involves a single visit during which an additional blood sample will be taken to analyze the presence of mutations in the virus related to resistance against antiretroviral drugs. Routine information related to the HIV infection will also be collected, including demographic data, HIV history, virological failure details, and laboratory parameters. Resistance testing will be performed on samples with viral loads over 200 copies/ml using advanced genetic sequencing techniques to detect mutations in the HIV-1 pol gene. Participants will provide clinical and demographic information through a questionnaire during the visit. Researchers will measure the selection of drug resistance mutations to dolutegravir and associated drugs within three months. The study is observational and involves careful laboratory and genetic analyses to assess viral resistance patterns in patients under treatment.