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Depression is a significant health concern among adolescents, with a notable number experiencing major depressive disorder or depressive symptoms. This research focuses on Dutch adolescents attending special schools, a group at higher risk for developing depression and suicidal thoughts. The study aims to screen these adolescents, offer a prevention program, and assess its impact on depressive symptoms, suicidality, anxiety, and somatic complaints through a randomized controlled trial. The study compares two groups one receiving the CBT-based preventive group training called Op Volle Kracht, adapted for special education settings, which includes eight weekly 45-minute sessions plus a follow-up meeting and a control group that is monitored and offered the training later if it proves effective. All participating schools teachers receive training to recognize and address depressive and suicidal symptoms. Clinical interviews and questionnaires are used at several points to measure outcomes. Participants will complete assessments at baseline, post-intervention, and at 6 and 12 months follow-up, including clinical interviews and self-report questionnaires about depressive symptoms and related concerns. Those showing suicidality will be referred to specialized care with parental involvement. The study includes ongoing guidance and mental health support as needed, aiming to evaluate the prevention programs effectiveness to better support adolescents in special education over a total period of up to 12 months post-intervention.