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Researchers are evaluating a special type of multisystemic therapy called MST-ID for adolescents aged 10 to 19 with severe behavioural problems living in families affected by intellectual disability ID. The study compares MST-ID to standard multisystemic therapy MST to see if MST-ID is better at reducing rule-breaking and other behavioural issues. The study uses both numbers-based assessments and families personal experiences to understand treatment effects and is sponsored by De Viersprong. The treatments involved are intensive, home-based therapies with 3 to 5 home visits each week over about three to five months. Both MST and MST-ID target adolescents behavioural problems by involving their family, school, and social environments. MST-ID differs by adapting its approach to the needs of families with ID, using simpler language, more structured sessions, and extra practice time to help families apply what they learn. Families receive either standard MST or the MST-ID specialization following usual referrals. Participants complete questionnaires at five time points start of treatment, end of treatment, and three follow-ups at 6, 12, and 18 months after treatment. Data collection includes standard MST monitoring and special interviews or discussions to capture families experiences. Researchers measure rule-breaking behaviour, other behavioural problems, parenting stress, out-of-home placements, school or work status, addictions, social networks, parenting skills, family relations, social support, and adolescent success with peers and education or work. The study lasts over 18 months with ongoing assessments to track impact.

Researchers are studying autism spectrum disorder ASD in older adults, focusing on improving recognition and diagnosis in mental health care. This research addresses the underdiagnosis and unfamiliarity of autism in older people and investigates whether training health care professionals and providing psycho-education programs can improve diagnosis rates and mental health outcomes. The study also aims to evaluate the effects of psycho-education on knowledge, acceptance, coping, resilience, psychological distress, and quality of life in older adults with ASD. The study involves two main interventions training mental health professionals in detecting and diagnosing ASD in older adults, and offering an adapted psycho-education PE program consisting of eight weekly group sessions lasting two hours each for older adults diagnosed or likely diagnosed with ASD. The training includes sessions for entire teams and diagnosticians, plus ongoing online expert consultations. The interventions are rolled out sequentially across multiple mental health organizations in a stepped wedge trial design. Participants aged 55 and older with confirmed or probable ASD will complete assessments at four time points over 9 to 15 months, including quality of life, acceptance of diagnosis, knowledge and recognition of ASD traits, coping skills, autistic traits, resilience, and psychological distress. A proxy chosen by the participant will also provide related information at two time points. The study collects data on diagnosis rates before, during, and after the intervention. Participation involves completing questionnaires and attending the PE sessions if assigned, with minimal burden expected.

Researchers are evaluating whether generalist treatment GIT-PD is not less effective than specialist treatments like Mentalization-Based Treatment MBT or Schema Therapy ST in improving the level of personality functioning in adults with severe personality disorders. The study also aims to find out which patient characteristics predict better responses to either specialist or generalist treatment. This pragmatic randomized controlled trial compares these approaches to help understand treatment options for severe personality disorders. Participants will be randomly assigned to receive either specialist treatmentMBT or ST, depending on availability and patient needsor generalist treatment following the Guideline-Informed Treatment for Personality Disorders GIT-PD. Specialist treatments require a minimum of 40 sessions or 12 to 24 months duration, while GIT-PD is a flexible, principle-driven approach lasting 12 to 18 months with assessment, modular treatment, and relapse prevention phases. Each site must offer both treatments, with GIT-PD being less intensive than the specialist therapies at that location. During the study, participants will complete various questionnaires and interviews at eight time points from enrollment through 30 months after starting treatment. Measurements include the Level of Personality Functioning Scale and the Semi-structured Interview for Personality Functioning, among others. Researchers will monitor symptoms, disability, quality of life, and treatment costs. This long-term follow-up allows detailed analysis of how each treatment affects personality functioning over time.