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Researchers are studying eating disorders, which are serious mental health conditions that affect eating behavior and overall quality of life. This research focuses on understanding how self-efficacy, or a persons belief in their ability to change, affects the outcome of treatment for eating disorders. The study also looks at how self-efficacy relates to motivation and self-esteem, and whether these factors improve during treatment. The treatment being studied is a brief, 10-session form of cognitive behavioral therapy called CBT-T, designed for disorders like bulimia nervosa, binge eating disorder, and other specified feeding or eating disorders. Participants will receive their usual CBT-T treatment, which includes weekly sessions over ten weeks. During treatment, patients are encouraged to face their fears and try new behaviors to increase their confidence and ability to manage their disorder. The study measures self-efficacy and treatment progress by having patients complete questionnaires at three points the start of treatment, at session four, and at the end of treatment session ten. Throughout the study, participants will fill out questionnaires assessing their eating disorder symptoms and levels of self-efficacy, motivation, and self-esteem. These assessments take place at the start, mid-treatment, and after completing all ten sessions. Researchers will analyze how these factors change and relate to treatment success. The total participation time includes the full ten-week treatment period with regular monitoring through these questionnaires.

Researchers are evaluating the effectiveness of the RISE blended behavioral intervention in people who have had a first stroke. The study aims to prevent major adverse cardiovascular events such as recurrent stroke, transient ischemic attack TIA, acute coronary events, and cardiovascular death over a one-year follow-up, compared to standard care. The study also examines the cost-effectiveness of the intervention and its impact on reducing sedentary behavior in community-dwelling stroke survivors with sedentary movement patterns. Participants are randomly assigned to either the experimental group receiving the 15-week RISE intervention alongside usual care or the control group receiving usual care only. The RISE intervention involves coaching by a primary care physiotherapist using behavior change techniques and the RISE eCoaching system, which includes an activity monitor, smartphone app with real-time feedback and e-learning modules, and a monitoring dashboard for the physiotherapist. Participants also receive support from someone in their social network. Usual care follows hospital-specific guidelines. Participants will be involved in baseline, post-treatment four months, and follow-up assessments at six, nine, and twelve months after randomization. These include wearing an activity monitor, completing questionnaires, and performing physical tests. Researchers measure major adverse cardiovascular events, 24-hour activity patterns including sedentary behavior, physical activity, and sleep, as well as cost-effectiveness, quality of life, healthcare utilization, and productivity losses. The study is designed to minimize burden with home or online sessions and non-invasive assessments, lasting approximately 3.5 hours per measurement period.

Researchers are evaluating the effects of two types of burst spinal cord stimulation SCS on pain relief and emotional aspects of pain in patients with Persistent Spinal Pain Syndrome Type 2 PSPS Type 2, also known as Failed Back Surgery Syndrome. The trial compares active recharge burst SCS versus passive recharge burst SCS, as no prior clinical studies have directly compared these two waveform methods. This randomized clinical trial aims to improve understanding of how different burst waveforms influence pain experience. The trial enrolls 96 patients across six Dutch hospitals who are randomly assigned to receive either active recharge or passive recharge burst SCS. After a successful trial period, patients will be permanently implanted with the assigned device. Active recharge burst uses negative pulses to directly compensate for charge differences, while passive recharge burst passively compensates for charge differences. Treatments are assessed over 12 months following implantation. Participants will complete various assessments including the Pain Catastrophizing Scale PCS at 6 months as the primary outcome. Secondary measures include pain ratings, patient vigilance, anxiety and depression scales, quality of life, disability index, patient global impression of change, and painDETECT questionnaires at baseline, after trial, and at 1, 3, 6, and 12 months post-implantation. The study monitors device usage and collects patient-reported outcomes to evaluate differences in pain relief and emotional response.

Researchers are evaluating whether generalist treatment GIT-PD is not less effective than specialist treatments like Mentalization-Based Treatment MBT or Schema Therapy ST in improving the level of personality functioning in adults with severe personality disorders. The study also aims to find out which patient characteristics predict better responses to either specialist or generalist treatment. This pragmatic randomized controlled trial compares these approaches to help understand treatment options for severe personality disorders. Participants will be randomly assigned to receive either specialist treatmentMBT or ST, depending on availability and patient needsor generalist treatment following the Guideline-Informed Treatment for Personality Disorders GIT-PD. Specialist treatments require a minimum of 40 sessions or 12 to 24 months duration, while GIT-PD is a flexible, principle-driven approach lasting 12 to 18 months with assessment, modular treatment, and relapse prevention phases. Each site must offer both treatments, with GIT-PD being less intensive than the specialist therapies at that location. During the study, participants will complete various questionnaires and interviews at eight time points from enrollment through 30 months after starting treatment. Measurements include the Level of Personality Functioning Scale and the Semi-structured Interview for Personality Functioning, among others. Researchers will monitor symptoms, disability, quality of life, and treatment costs. This long-term follow-up allows detailed analysis of how each treatment affects personality functioning over time.