Zeist

This research aims to improve treatments for eating disorders by studying factors that may influence how well patients respond to therapy. It focuses on whether a person's confidence in their ability to recover, called self-efficacy, affects treatment results. The study also looks at how self-efficacy, motivation, and self-esteem are related in patients undergoing therapy for eating disorders such as bulimia nervosa, binge eating disorder, and other specified feeding or eating disorders. Participants receive Cognitive Behavioral Therapy - Ten (CBT-T), a brief treatment consisting of 10 weekly sessions. During therapy, patients are encouraged to face their fears and practice new behaviors to support recovery. Self-efficacy is measured at the start, after four sessions, and at the end of the treatment using questionnaires. The study explores whether changes in self-efficacy during therapy relate to better outcomes. Patients will complete questionnaires at three points: the beginning of therapy, session four, and session ten. Researchers will evaluate their eating disorder symptoms and examine how self-efficacy and related factors change over time. The main outcome is treatment success measured by the ED-15 questionnaire at these three times. This study helps understand how psychological factors influence recovery in eating disorder treatments.

This research evaluates the effectiveness of the RISE blended behavior change intervention in people who have experienced their first stroke. The study aims to prevent major adverse cardiovascular events such as recurrent stroke, transient ischemic attacks, acute coronary events, and cardiovascular death over a one-year follow-up period compared to standard care. It also investigates the intervention's impact on reducing sedentary behavior after hospital discharge in community-dwelling stroke survivors with sedentary movement patterns. Approximately 950 to 1000 participants are expected to be enrolled to account for loss to follow-up. Participants are randomly assigned to an experimental group receiving the 15-week RISE intervention alongside usual care or to a control group receiving only usual care. The RISE intervention involves coaching by a primary care physiotherapist who supports participants in balancing their 24-hour activity pattern, focusing on reducing and interrupting sedentary time to increase physical activity. This coaching includes the use of an activity monitor, a smartphone application with real-time feedback and e-learning modules, and a dashboard for the physiotherapist. Support from someone in the participant's social network is also included. Control group participants receive hospital-specific standard care. Participants will undergo assessments at baseline, immediately post-treatment (four months), and at six, nine, and twelve months after randomization. These assessments include wearing activity monitors, completing questionnaires, and performing physical tests, all of which are non-invasive and conducted either online or at home. Researchers monitor the occurrence of major adverse cardiovascular events as the primary outcome. The study's burden and risks are considered low, with physiotherapist visits conducted at home or online, and participants are physically capable of completing the required activities.

Researchers are evaluating two methods of delivering spinal cord stimulation (SCS) electrical charge for patients with Persistent Spinal Pain Syndrome Type 2 (PSPS Type 2), also known as Failed Back Surgery Syndrome. This trial compares active recharge burst stimulation with passive recharge burst stimulation to see if there are differences in pain relief and motivational-emotional aspects of pain. This multicenter randomized clinical trial is conducted in six Dutch hospitals and aims to assess which burst stimulation waveform might better affect patient outcomes. Participants will be randomly assigned to receive either active recharge burst or passive recharge burst spinal cord stimulation. After a successful trial period, patients will be permanently implanted with the assigned neurostimulation device. Active recharge burst uses negative pulses to directly compensate for charge differences, while passive recharge burst uses a recharge pattern that passively balances charge differences. The study involves 96 patients and follows them up at multiple time points over a year after implantation. During the study, patients will complete several assessments including the Pain Catastrophizing Scale (primary outcome measured at 6 months), Numeric Pain Rating Scale, Patient Vigilance and Awareness Questionnaire, Hospital Anxiety and Depression Scale, quality of life questionnaires, Oswestry Disability Index, Patient Global Impression of Change, and painDETECT questionnaires. These are completed at baseline, after the trial period, and at 1, 3, 6, and 12 months post-implantation. The study monitors pain experience, emotional and motivational aspects of pain, and overall quality of life throughout the participation period.

Researchers are investigating whether a generalist treatment approach called Guideline-Informed Treatment for Personality Disorders (GIT-PD) is as effective as specialist treatments, specifically Mentalization-Based Treatment (MBT) and Schema Therapy (ST), in improving personality functioning in patients with severe personality disorders. The study also aims to identify patient characteristics that predict who benefits more from each type of treatment. This is a pragmatic randomized controlled non-inferiority trial comparing generalist and specialist therapies for severe personality disorders. Participants are randomly assigned to receive either specialist treatment (MBT or ST) or generalist treatment (GIT-PD). MBT and ST are manualized, specialist psychotherapies lasting 12 to 24 months with at least 40 sessions, focusing on different therapeutic approaches. GIT-PD is a flexible, principle-driven treatment lasting 12 to 18 months and includes assessment, modular treatment (group or individual), and a follow-up phase focused on relapse prevention. Generalist treatment is designed to be less intensive than specialist therapies at the same site. During the trial, participants complete various questionnaires and semi-structured interviews at eight time points from enrollment through 30 months after treatment start. The study measures personality functioning using the Level of Personality Functioning Scale - Brief Form 2.0 (LPFS-BF 2.0) and the Semi-structured Interview for Personality Functioning (STiP-5.1). These assessments help evaluate treatment effects and predict patient outcomes. Participants engage in their assigned therapy while researchers collect data before, during, and after treatment to monitor progress and safety.