Moss

Researchers are evaluating if patients with acute heart failure can achieve the same level of heart failure medication management through digital follow-up at home compared to traditional hospital visits, based on the STRONG-HF strategy. This study addresses the challenge of low use of recommended heart failure therapies despite evidence showing they reduce mortality, aiming to improve care delivery by testing remote medication up-titration and follow-up. The trial builds on the STRONG-HF trials success, which showed better outcomes with early medication adjustment and follow-up in specialized clinics but faced barriers due to frequent hospital visits. Participants will be randomly assigned to one of two groups one receiving follow-up and heart failure medication management at home via telecommunication led by specialized nurses, including home visits at 1, 2, 3, and 6 weeks plus a primary care physician visit around week 2 the other group receiving follow-up and medication management at hospital outpatient clinics on the same schedule. Both groups follow the STRONG-HF intensive care strategy with early and rapid medication up-titration to at least half the maximum tolerated doses at discharge and then to maximum tolerated doses after 2 weeks, with safety visits at weeks 1, 3, and 6. During the 90-day study period, participants will be monitored for medication doses, heart function via echocardiography, blood tests including NT-proBNP, quality of life assessments, self-care, and patient satisfaction. Readmissions and survival will be tracked for up to 24 months. Follow-up visits occur weekly during the first 6 weeks, and researchers will assess treatment adherence, adverse events, and healthcare costs. This approach aims to reduce the burden on patients and healthcare systems while maintaining effective heart failure care.

Osteoarthritis of the joint between the forearm bones at the wrist, called the distal radioulnar joint DRUJ, can cause pain and reduce the ability to lift and rotate the forearm. This condition often develops after fractures, ligament injuries, or degenerative wrist disease. Researchers are comparing two surgical treatmentsthe Darrach procedure, which removes the ulnar head, and ulnar head replacement with a prosthetic implantto determine which method provides better function and fewer complications in patients with stable but painful DRUJ osteoarthritis. The study involves two groups one undergoing the Darrach procedure and the other receiving a ulnar head replacement using the Herbert Ulnar Head Prosthesis. The surgeries are performed at several hand surgery centers in Norway, following standardized methods. Both groups receive the same postoperative care and follow-up schedule. Participants are randomly assigned to one of the two surgical options to fairly compare outcomes. Participants will be assessed before surgery and then followed up at 3 months, 1 year, and 5 years after the procedure. Evaluations include range of motion, grip strength, functional scores such as the Norwegian version of Quick DASH, patient-related wrist and hand evaluations, pain scales, and monitoring for any complications or additional surgeries. The study aims to gather detailed long-term data on how each surgery affects wrist function and pain over five years.

Researchers are studying predictors of clinical course and treatment response in patients receiving Dialectical Behaviour Therapy DBT in Norway. The study focuses on individuals with repeated self-harm behavior and borderline personality disorder, aiming to understand which patient characteristics and treatment factors influence outcomes such as symptom levels, functioning, problem behaviors, and emergency service use. This research is a collaboration between The National Centre for Suicide Research and Prevention and clinical units with DBT programs. Participants receive either DBT adapted for adolescents DBT-A over 20 weeks or the standard DBT for adults lasting 52 weeks. DBT-A includes weekly individual therapy, multifamily skills training, family therapy as needed, and telephone coaching. Standard DBT involves weekly individual therapy, weekly skills training, and telephone coaching outside sessions. Assessments occur before treatment, during treatment at several points, at treatment end, and follow-up, using interviews and patient self-reports. During the study, patients provide self-report data electronically on tablets and via a mobile app several times daily. Therapists enter interview and rating data into the database. The main outcomes measured include self-harm behavior, suicidal ideation, depressive symptoms, borderline symptoms, and hopelessness at various intervals. The study collects data over time to evaluate clinical changes and treatment impact, with participation lasting through the treatment and follow-up periods.