Nesoddtangen

Researchers are evaluating the effects of a progressive, sub-symptom threshold aerobic exercise program on adults with persistent symptoms after mild traumatic brain injury mTBI, also known as post-concussion syndrome PCS. This condition affects 20% to 30% of individuals following mTBI and can cause ongoing symptoms including exercise intolerance and autonomic nervous system ANS dysfunction. The study aims to better understand the neurobiological factors involved in PCS and to develop targeted interventions for those with lasting symptoms. Participants with exercise intolerance will be randomly assigned to either an intervention group or a control group. The intervention group will receive a personalized aerobic exercise program to be done approximately 3 to 5 times per week for 12 weeks, exercising at 80-90% of their maximum heart rate threshold assessed by the Buffalo Concussion Treadmill Test BCTT. They will have one guided session weekly for the first three weeks and will perform other sessions independently, using various activities like walking, jogging, or swimming, monitored by heart rate and perceived exertion scales. The control group will receive standard outpatient rehabilitation from a multidisciplinary team. During the study, participants will undergo medical examinations and assessments including BCTT, Arterial Spin Labeling MRI, and the Cold Pressor Test to evaluate ANS function and symptom burden. Symptom severity will be measured using the Rivermead Post-concussion Symptom Questionnaire and other patient-reported outcomes. Exercise adherence will be tracked through diaries and weekly follow-ups. The main outcome is symptom improvement after 12 weeks, with safety and quality of life also monitored. The study lasts 12 weeks with assessments at baseline and after the intervention.