Sandnes

Migraine is a neurological condition causing moderate to severe headaches often accompanied by nausea, vomiting, and sensitivity to light and sound. This research aims to assess how well atogepant works in adults with migraine when used in everyday medical practice. Atogepant is an approved preventive treatment for migraines, and the study will include about 1000 adult participants prescribed this medication by their doctors worldwide. Participants will take atogepant tablets orally as prescribed by their healthcare providers following usual medical care. The study will observe participants over a two-year period without requiring extra treatments or procedures beyond their regular clinical visits. These visits will occur at hospitals or clinics according to each participant's routine care schedule. During the study, participants will attend regular check-ups where researchers will monitor their health and migraine symptoms. The main outcome measured will be the percentage of participants who report feeling "much better" or "very much better" by week 12, based on their own impression of change. There are no additional burdens expected for participants beyond their normal treatment and follow-up appointments.

Researchers are evaluating the Nurse Family Partnership (NFP) program in Norway to help reduce child abuse and social inequality. This randomized controlled trial will enroll 700 first-time pregnant mothers over three years, comparing those receiving NFP services with others receiving standard care. The study focuses on violence affecting mothers and their children, and also looks at mental health, injuries, and overall well-being. Participants assigned to the treatment group will receive regular home visits from nurses starting in pregnancy and continuing until their child turns two years old. The control group will receive usual community services and care available. The study runs from recruitment during pregnancy through the child's second birthday, allowing for detailed observation and support during this crucial early period. Mothers will complete questionnaires during their last trimester and when their child is 6, 12, and 24 months old, assessing partner violence, parenting skills, coping, and child development. Health staff will perform standardized developmental tests at 24 months. The study will also use health data records to examine a broad range of health outcomes and will analyze the cost-effectiveness of NFP compared to current services. Safety and changes in violence and injuries will be tracked throughout the study period.