Abbottabad

Researchers are evaluating the effects of Alternate Nostril Breathing exercise compared to Incentive Spirometry on lung function in adults with asthma. The study aims to measure improvements in lung capacity and asthma control over a 6-week period. Participants are randomly assigned to one of two groups one group practices Alternate Nostril Breathing involving controlled nostril breathing cycles for 10 minutes, while the other group performs breathing exercises with an Incentive Spirometer, involving deep inhalations and breath holds repeated multiple times daily. This randomized, single-blind study compares these two interventions over 6 weeks. During the study, participants will have lung function tests including forced expiratory volume in 1 second, forced vital capacity, and peak expiratory flow rate measured. They will also complete asthma control and quality of life questionnaires. The research team monitors adherence and lung function changes throughout the 6-week intervention to assess the impact of the breathing exercises.

Researchers are evaluating the effects of orlistat on the metabolic and hormonal features of women with polycystic ovary syndrome PCOS, a common endocrine and metabolic disorder affecting women of reproductive age. The study aims to determine whether orlistat, combined with lifestyle changes, can improve hormonal balance, glucose metabolism, lipid levels, liver function, body measurements, non-alcoholic fatty liver disease, and quality of life in women diagnosed with PCOS according to the Rotterdam criteria. In this randomized controlled trial, 120 women aged 18 to 45 with PCOS will be assigned to one of two groups. One group will receive oral orlistat capsules twice daily plus standard lifestyle advice including a healthy diet and at least 30 minutes of daily walking or cycling, while the other group will receive matching placebo capsules plus the same lifestyle advice. The intervention lasts for three months. Participants will have a baseline evaluation, followed by telephone follow-ups at one and two months to check treatment adherence, and a final in-person assessment after three months. Researchers will measure changes in PCOS features, hormonal levels such as LH, FSH, AMH, and testosterone, blood glucose and insulin markers, lipid profile, liver tests, ultrasound grading of fatty liver, body measurements, and quality of life related to PCOS. This study will provide data on orlistats role as an adjunctive treatment for PCOS.

This research aims to evaluate how vestibular rehabilitation therapy compares to conventional stroke therapy in improving balance and reducing post-stroke fatigue in stroke patients. Stroke causes sudden brain damage due to blood vessel issues, often leading to balance problems and fatigue that can persist even after neurological recovery. The study focuses on these common issues because vestibular dysfunction may contribute to falls and fatigue after stroke, affecting quality of life and daily functioning. Participants will be randomly assigned to one of two treatment groups. One group will receive vestibular rehabilitation therapy, which includes exercises involving eye and head movements, balance training, and tasks that promote gaze stability and sensory integration. The other group will receive conventional treatment, consisting of balance exercises, walking training, weight shifting, and muscle strengthening. These treatments are delivered over an 8-week period. During the study, participants will be assessed using the Berg Balance Scale and Fatigue Assessment Scale at 8 weeks to measure changes in balance and fatigue. Researchers will monitor progress throughout the treatment period to evaluate the effects of each therapy. Participants will be involved in exercises and assessments designed to track improvements in post-stroke fatigue and balance, helping to understand which therapy better supports recovery.