Mansehra

This trial studies adolescents aged 10 to 19 years with spastic diplegic cerebral palsy, a condition that affects movement, balance, and coordination mainly in the lower limbs. It aims to compare the effects of fully immersive Mixed Reality combined with standard physical therapy versus standard physical therapy alone on improving balance and coordination. The study is a single-blinded randomized controlled trial involving 40 participants. Participants will be randomly assigned to two groups. One group will receive interactive Mixed Reality therapy using the Meta Quest Pro system alongside standard physical therapy exercises like balance training, gait training, and strengthening, three times a week for eight weeks. The other group will receive only the standard physical therapy program at the same frequency and duration. The Mixed Reality sessions include games and activities designed to engage and improve motor skills. Throughout the study, assessments of balance using the Pediatric Balance Scale and coordination using the Comprehensive Coordination Scale will be conducted before treatment, at four weeks, and after eight weeks of intervention. Participants will attend regular therapy sessions and evaluations to track progress. The results aim to provide evidence on whether immersive Mixed Reality can enhance rehabilitation outcomes for adolescents with this form of cerebral palsy.

This research aims to compare Sensory Integration Therapy and Conventional Physical Therapy to evaluate their effects on gross motor function in children with athetoid cerebral palsy. This randomized controlled trial focuses on children aged 6 to 12 years diagnosed with this condition, exploring how these therapies may influence motor abilities. Participants receive either a combination of Sensory Integration Therapy and Conventional Physical Therapy or Conventional Physical Therapy alone. Both treatments involve three sessions per week for six weeks, each lasting 45 minutes. Sensory Integration Therapy includes activities such as vestibular control, proprioceptive input, midline and postural stability, and tactile-motor integration, while Conventional Physical Therapy focuses on stretching, strengthening, balance training, and gait and functional mobility exercises. During the study, children will be assessed using the Gross Motor Function Measure from the start to the last week of treatment. Researchers will monitor progress through physical function evaluations and ensure safety throughout the trial. Participant involvement lasts for the six-week treatment period, with regular sessions to track changes in motor skills and therapy effects.

Stroke often leads to weakness, poor coordination, and balance problems, which can reduce a persons independence. HABIT-ILE Hand-Arm Bimanual Intensive Therapy Including Lower Extremity is a rehabilitation approach designed to improve motor control, balance, and functional independence by focusing on coordinated movements involving both the upper and lower limbs. This study aims to evaluate how effective HABIT-ILE is in improving balance and coordination in stroke survivors aged 40 to 60 years. Participants are divided into two groups one receives the HABIT-ILE therapy, which involves intensive, progressively challenging exercises for two hours daily over three weeks focusing on both upper and lower limbs. The other group receives conventional physical therapy consisting of range of motion, stretching, strengthening, and muscle relaxation exercises during 30-minute sessions. This randomized controlled trial compares these two approaches to assess their impact on stroke recovery. During the six-month study period, participants undergo assessments including the Finger-to-Nose Test, Berg Balance Scale, and 6-Minute Walk Test to measure improvements in coordination, balance, and mobility. Data analysis includes repeated measures ANOVA to evaluate changes over time. The study monitors participant progress closely to determine the therapys effects on functional outcomes and mobility after stroke, with the overall goal of enhancing quality of life.

Children with spastic diplegic cerebral palsy often face difficulties with upper limb movement, coordination, and functional hand use, which impacts their independence in daily life. This research aims to compare three rehabilitation approaches Proprioceptive Neuromuscular Facilitation PNF alone, Task-Oriented Training TOT alone, and a combination of both. The study involves children aged 6 to 12 years with mild to moderate motor impairment classified by the Gross Motor Function Classification System GMFCS levels I to III. Participants will be randomly assigned to one of three groups receiving supervised physiotherapy sessions lasting 45 minutes, three times per week for six weeks. The PNF group will perform specific diagonal upper limb movements, the TOT group will practice functional activities like reaching and grasping, and the combined group will receive both interventions within each session. The goal is to assess which approach best improves upper extremity function. Throughout the study, assessments will be conducted at the start, mid-point 3 weeks, and end 6 weeks using tools such as the Melbourne Assessment of Unilateral Upper Limb Function MA2 for movement quality, Pediatric Evaluation of Disability Inventory-Functional Skills Scale PEDI-FSS for independence in daily activities, and goniometric measurements to evaluate joint range of motion. These evaluations will help determine changes in upper limb function and independence resulting from the different rehabilitation methods.

Post-stroke fatigue PSF, characterized by an overwhelming feeling of exhaustion unrelated to exertion and not relieved by rest, is a common and challenging outcome experienced by stroke survivors. This trial aims to evaluate how two types of physical trainingGraded Activity Training and Task-Oriented Trainingaffect fatigue levels in post-stroke patients. By improving physical endurance, the study hopes to develop better fatigue management strategies, enhance mobility and gait, reduce caregiver and healthcare system burdens, and ultimately improve the quality of life for stroke survivors. Participants will be randomly assigned to one of two training programs. Graded Activity Training involves two weekly 2-hour sessions over 6 weeks, including treadmill walking, core muscle exercises, and home tasks, with heart rate monitored continuously and exertion levels tracked using Borgs Scale. Task-Oriented Training includes similar 2-hour sessions with activities such as walking on different surfaces, sit-to-stand exercises, and stair climbing, with warm-up and cool-down periods and gradual increases in task difficulty over 6 weeks. During the study, researchers will assess fatigue using the Fatigue Assessment Scale after 6 weeks, along with mobility and gait through the Timed Up and Go test and Dynamic Gait Index. Continuous monitoring of heart rate and exertion during sessions helps ensure appropriate training intensity. The total participation duration covers the 6-week intervention period, focusing on measuring changes in fatigue and physical function to identify optimal rehabilitation approaches.

Researchers are studying the effects of adding the Scalene Hold Relax Technique to conventional physical therapy exercises on lung function in adults with allergic asthma. This trial aims to see if this combined approach improves breathing and asthma control compared to standard therapy alone. The study is interventional and randomized, involving adult patients aged 20 to 44 years with asthma. Participants will receive one of two treatments the Scalene Hold Relax Technique or conventional physical therapy. The Scalene Hold involves holding the arms behind the back while gently tilting the head toward the shoulder for 5 to 10 seconds, repeated multiple times on each side over 1 to 4 weeks as needed. The conventional therapy includes diaphragmatic breathing exercises and Buteyko breathing exercises performed 2 to 3 days per week for up to 4 weeks. During the study, participants will be monitored over 4 weeks with assessments such as the Asthma Control Questionnaire, Asthma Control Test, Lara Asthma Symptoms Scale, and lung function tests including FEV1, FVC, and PEF. These measures will help evaluate changes in asthma symptoms and breathing ability. The study team will observe participant responses and adherence to the exercises throughout the treatment period.