Sintra

This research aims to evaluate the feasibility, safety, and efficacy of Exercogs4, a novel exergaming platform combining augmented reality AR and gamification, as part of a community-based dementia prevention program for older adults at risk. The study focuses on adults aged 55 years or older who have at least one modifiable dementia risk factor, assessing effects on cognitive, physical, and social domains. It is a randomized, controlled, assessor-blind, parallel-group, multicenter trial designed to provide robust evidence for digital multidomain interventions in dementia prevention. Participants will be randomly assigned to either the Exercogs4 intervention group or an active control group. Both groups will engage in supervised 60-minute sessions three times per week for 24 weeks. The Exercogs4 program integrates cognitive exercises attention, memory, executive function, physical training balance, gait, coordination, and social activities cooperative and competitive tasks within a gamified AR environment with adaptable difficulty. The control group will perform similar multidomain exercises without AR or gamification. Assessments occur at baseline, 12 weeks, 24 weeks end of intervention, and 4 and 8 weeks post-intervention. Participants will undergo comprehensive evaluations including cognitive testing MoCA, physical performance SPPB, and social participation WHODAS 2.0. Additional measures include usability, quality of life, safety monitoring for adverse events, and modifiable risk factor changes. Adherence is tracked through automated logs and therapist diaries. The study duration includes the 24-week intervention plus follow-up assessments, aiming to gather evidence on the usability, safety, and potential benefits of this multidomain digital therapeutic approach for dementia prevention.