Ga Rankuwa

Researchers are evaluating the immune response and safety of the Hecolin4 recombinant hepatitis E vaccine in healthy children and adults, including those with and without HIV. The study aims to show that the vaccines immune response in children aged 2 to 17 years is not worse than in healthy adults aged 18 to 45 years. It also compares immune responses between HIV positive and negative adults and assesses safety across different age groups. Participants receive the vaccine or placebo through intramuscular injections according to their age group and HIV status. Adults 18-45 years receive three doses at 0, 1, and 6 months. Children and adolescents are divided into groups receiving either three doses, two doses, or placebo on similar schedules. Blood samples are collected at multiple timepoints before and after vaccination to measure immune response and safety markers. Participants are monitored closely at the study site after each injection for immediate reactions and keep diary cards to record side effects for 7 days. Safety data, including serious and medically attended adverse events, are collected throughout the study. The primary outcome is the rate of immune response measured 4 weeks after the third dose. The study includes follow-up blood collections for up to 2 years to assess long-term immune responses.

Researchers are evaluating the Prostate Cancer Patient Empowerment Program PC-PEP in men diagnosed with prostate cancer to improve mental health and quality of life. The study focuses on addressing side effects from common treatments like surgery and radiation, which often cause urinary incontinence, sexual dysfunction, and reduced physical function. It aims to support mental health and overall well-being in men undergoing curative treatment for prostate cancer. The PC-PEP is a six-month home-based program that includes aerobic and strength training exercises, pelvic floor muscle training, meditation, social connection, and healthy lifestyle practices. Participants receive daily reminders via text or email to encourage engagement, and they are paired with peers for social support. The program also involves educational materials delivered through multimedia and in-person sessions to teach life skills and habits that may reduce treatment-related side effects. Participants will be involved in regular assessments including online surveys at the start, 6, 12, and 24 months, and weekly compliance surveys during the program. Researchers will measure mental health as the primary outcome and other factors such as physical and mental quality of life, urinary and sexual function, sleep quality, diet, anxiety symptoms, and relationship satisfaction. The study also monitors health care utilization and self-efficacy over a two-year period.