Carouge

Researchers are investigating a new approach to improve arm movement recovery in people who have had a stroke and continue to experience weakness or poor control in one arm. The study focuses on enhancing brain network connections, especially between the primary motor cortex and parietal cortex, to promote motor learning and recovery. This approach uses a non-invasive brain stimulation method called intermittent theta-burst stimulation (iTBS) combined with interactive motor training. Participants with chronic stroke-related upper limb impairment will be randomly assigned to receive either active multifocal iTBS targeting both the primary motor cortex and parietal cortex or a sham (placebo) stimulation. Both groups will complete identical motor training sessions using a tablet-based device called REAtouch® Lite 2, which guides goal-directed reaching exercises. The intervention involves two consecutive days of stimulation plus 45 minutes of training each day. Ten healthy participants will also undergo the same training without brain stimulation to provide comparison data. Participants will attend six visits over about 10 days for assessments including motor performance tests on the tablet, clinical motor scales (Fugl-Meyer Assessment for Upper Extremity), and resting-state EEG scans to evaluate brain connectivity changes. The main outcome measured is improvement in motor performance from baseline to one week after treatment. Secondary outcomes include short-term motor learning, retention of skills, movement quality, and changes in brain network connectivity. This trial aims to evaluate whether combining multifocal brain stimulation with targeted training can enhance recovery after stroke.

Post-stroke fatigue is a common and lasting symptom experienced by many adults after a stroke. It involves persistent tiredness that can be physical, mental, or emotional and does not always get better with rest. This research study seeks to better understand how adults living in French-speaking Switzerland describe their fatigue, how strong and often it occurs, how it affects their daily lives and quality of life, and what coping strategies they use. The study is observational and collects information through a questionnaire. Participants will complete one anonymous questionnaire either online or on paper. This questionnaire includes structured questions with rating scales and multiple-choice items, as well as open-ended questions that allow participants to share their personal experiences. The study does not include any treatments, medical tests, or follow-up visits. Participation is voluntary and confidential, with no identifying information collected. During the single study visit, researchers will gather information about fatigue severity, presence, intensity, frequency, and functional impact on daily activities. They will also assess quality of life related to fatigue, coping strategies, and social or professional support. The study aims to gain insights that may help improve rehabilitation care for post-stroke fatigue through a mixed-methods approach combining quantitative and qualitative data.