Muttenz

Researchers are establishing a European registry and sample sharing network called EUREKA to collect new cases of AL amyloidosis from referral centers and their satellite sites across Europe. This observational study aims to use advanced molecular technologies and big data analysis, including artificial intelligence, to better understand the disease mechanisms, improve early diagnosis, and guide treatment decisions. The study also seeks to describe the natural history of AL amyloidosis in patients receiving modern anti-plasma cell therapies and to refine methods for detecting minimal residual disease after treatment. The study involves creating a biorepository and sample sharing network to study disease-causing light chains and plasma cells using cutting-edge molecular techniques. A dedicated site will support the consortium with big data and AI applied to health data. Participants will be followed over time at participating centers, with data collected to assess outcomes such as mortality and hematologic relapse in those achieving complete response to therapy. Participants will be involved through regular follow-up visits at their treatment centers, with collection of clinical data and biological samples. Researchers will monitor outcomes including mortality at 24 months after diagnosis and rates of relapse in patients with minimal residual disease. The study duration allows for long-term observation to better understand disease progression and response to treatment in a real-world setting.

Researchers are evaluating the effectiveness of training the posterior thigh muscles using real-time electromyographic EMG biofeedback compared to training without feedback. The study focuses on healthy, physically active adults aged 18 to 40 and aims to improve hamstring activation methods to help prevent muscle injuries. This controlled study is conducted in a single center and involves a parallel-group design with random assignment. Participants complete a 5-week training program with the Hamshell device, designed to target hamstring and gluteus maximus muscles at extended knee angles. They attend 10 sessions twice weekly, each lasting about 30 minutes. One group trains with visual EMG feedback to optimize muscle activation, while the control group performs the same exercises without feedback. The first and middle sessions are supervised to ensure proper technique and progression, with EMG recordings taken during these sessions. Participants undergo assessments before and after the training program, including muscle strength tests, flexibility measurements, electromyographic recordings, and functional performance evaluations such as countermovement jumps. Training adherence and perceived exertion are tracked throughout. The primary outcome is the integrated EMG activity of the biceps femoris muscle during a modified Nordic hamstring exercise. Secondary outcomes include various strength, flexibility, and functional measures. The entire study period is planned to last about 12 months, including recruitment and follow-up.