Onex

Chronic leg and foot ulcers are wounds that do not heal properly over 4 to 8 weeks despite standard care, often due to vascular problems like chronic venous insufficiency and peripheral artery disease. These conditions reduce blood flow, limiting oxygen and nutrients needed for healing, and cause ongoing inflammation and infection. This trial evaluates a new combined optical and magnetic stimulation COMS therapy alongside standard care to improve healing, pain, quality of life, and economic outcomes for patients with venous leg ulcers, including those with arterial complications. Participants will be randomly assigned to receive either standard care alone or standard care plus COMS therapy. Standard care includes wound cleaning, dressing changes, debridement, analgesics as needed, and compression therapy according to guidelines. The COMS treatment is applied 2 to 3 times per week for at least 8 weeks using a specialized device during standard care procedures. If patients receive care at home, trained caregivers will perform these treatments. During the 24-week study, participants will have regular assessments to monitor wound healing, pain, quality of life, and ulcer recurrence. Researchers will measure the percent reduction in wound area as the primary outcome after 24 weeks, along with complete wound closure and time to healing. Safety and device usability will also be evaluated. The study is single-blinded with data assessors unaware of group assignments and includes multiple clinical sites across several countries.

Suicide is a leading cause of death among teenagers, and preventing it has become a public health priority. This research aims to evaluate a brief primary suicide prevention intervention specifically for vulnerable adolescents, such as those in juvenile detention, at risk of dropping out of school, undergoing psychiatric treatment, belonging to sexual or gender minorities, affected by chronic conditions, or facing relational or family problems. The study uses a randomized controlled trial to test the interventions impact on suicide awareness, psychological distress, and suicidal thoughts. The intervention being studied is a 90-minute group psychoeducation session conducted by trained staff and a psychologist. It includes lectures, group discussions, and quizzes about suicide facts, myths, risk factors, warning signs, and ways to seek help. Participants are divided into groups of 5 to 15, averaging 10. The control group participates in an art-based workshop focused on slam poetry. After the study, control group participants receive informational flyers about suicide prevention. Participants aged 14 to 25 with good knowledge of French and meeting vulnerability criteria are involved. The study measures outcomes including a composite of suicide awareness one week and three months after the intervention, knowledge of suicide and local resources, suicidal thoughts, psychological distress, and access to suicide prevention. Assessments occur at baseline, one week, and three months post-baseline, with attention to participant retention and safety throughout the study period ending in 2028.