Onex

Chronic leg and foot ulcers are wounds that do not heal properly over several weeks, often due to blood flow problems caused by conditions like chronic venous insufficiency or peripheral artery disease. These ulcers share biological challenges such as reduced oxygen and nutrient supply, leading to impaired cell functions, persistent inflammation, and infections that prevent healing. Standard treatments include compression therapy, physical activity, and surgical procedures to improve blood flow and support wound repair. This trial evaluates a combined treatment called Concurrent Optical and Magnetic Stimulation (COMS) alongside standard care, compared to standard care alone, in patients with venous leg ulcers or venous leg ulcers with peripheral artery disease. COMS therapy uses magnetic stimulation and light therapy to activate cellular processes that promote healing, such as increased energy production, cell growth, blood vessel dilation, and reduced inflammation. Patients in the intervention group receive COMS treatment 2-3 times weekly for at least 8 weeks, with a minimum of 16 sessions, during their usual wound care procedures. Participants will be followed for a total of 24 weeks. During this time, researchers will monitor wound healing progress, including the percent reduction in wound area at 24 weeks. Assessments include wound evaluations, quality of life measures, pain levels, and device usability. The study is conducted across multiple centers in several European countries, with treatments and follow-up occurring in outpatient or home care settings. Safety and effectiveness data will be analyzed to understand the impact of COMS therapy on chronic vascular ulcers.

Suicide is a leading cause of death among teenagers, and preventing it is a public health priority. This research aims to evaluate the effectiveness of a brief primary suicide prevention intervention specifically designed for vulnerable adolescents. These adolescents include those detained in juvenile detention centers, at risk of dropping out of school, undergoing psychiatric treatment, belonging to sexual or gender minorities, affected by chronic conditions, or facing family or relational problems. The study focuses on improving suicide awareness, reducing psychological distress, and lowering suicidal thoughts in this high-risk group. The study compares two behavioral interventions: a psychoeducation workshop as the primary suicide prevention method, and an art-based control intervention involving a slam poetry workshop. Participants will be randomly assigned to either group to assess the impact of the suicide prevention workshop on their awareness and mental health. The trial includes adolescents aged 14 to 25 years who have good knowledge of French and consent to participate. During the study, researchers will measure a composite outcome of suicide awareness one week after the intervention. They will also explore challenges such as access to prevention programs and non-response bias within vulnerable populations. Participants will be closely monitored for any interference with their psychiatric care, and safety considerations will be addressed throughout the study period.