Luzhou District

Researchers are evaluating the efficacy and safety of the combination of divarasib and pembrolizumab compared with pembrolizumab combined with pemetrexed and either carboplatin or cisplatin. This study focuses on adults with previously untreated, advanced or metastatic non-squamous non-small cell lung cancer NSCLC that has a KRAS G12C mutation. The goal is to assess these treatments as first-line options in this specific lung cancer population. Participants will be randomly assigned to one of two groups. One group will take divarasib orally once daily and receive pembrolizumab through an intravenous infusion every three weeks. The other group will receive pembrolizumab, pemetrexed, and either carboplatin or cisplatin via intravenous infusions every three weeks. Treatment continues with these schedules, following the study protocol for up to approximately five years of follow-up. During the study, participants will have regular assessments to monitor their health and response to treatment. These include imaging and clinical evaluations to measure progression-free survival and overall survival for up to five years. Researchers will also track quality of life, symptom changes, treatment side effects, and adverse events using questionnaires and patient-reported outcomes. Safety monitoring and detailed evaluations will help understand the effects of the treatments over the study duration.

Researchers are evaluating a new approach to early infant motor development screening using an artificial intelligence AI algorithm combined with a mobile application called Baby Go version 3.0. This observational study focuses on infants aged 2 to 18 months, including both term and preterm infants, aiming to improve early detection and follow-up of motor disorders. The study also compares parental reports with AI-driven assessments and investigates the usability of the app for parents and clinicians. The study involves parents using the Baby Go app at home to record videos of their infants movements in various positions, such as prone, supine, sitting, and standing, every two weeks between 2 and 18 months of age. These videos are uploaded through the app for AI analysis and comparison with trained physiotherapist annotations. The study includes around 100 preterm infants, 20 term infants, 120 parents, and 2 clinicians. The app also provides educational and follow-up functions to support parents. Participants will be assessed using the Alberta Infant Motor Scale and walking age attainment measures. Parents and clinicians will complete surveys about their experience with the app at specific infant ages. The study will analyze AI model accuracy, parental perception, and the predictive validity of motor assessments. Overall, the study involves remote monitoring, video evaluations, user feedback, and data analysis over the infants first 18 months.

Researchers are studying older adults who have been newly diagnosed with locally advanced or advanced non-small cell lung cancer and their primary family caregivers. The study aims to understand the current physical and emotional challenges these patients and caregivers face, as well as to evaluate the effects of a specialized Nurse-Led Caregiver Support Model ICSM designed to improve caregiver quality of life and resource use. The study has two phases over three years. Phase I is a cross-sectional study assessing distress, unmet needs, social support, and health practices among patients and caregivers. Phase II is a 12-month randomized trial comparing two groups one receiving the ICSM plus oncology case manager care and usual hospital care, and the other receiving oncology case manager care with usual hospital care. The ICSM intervention includes nurse-led education, counseling, symptom management, emotional coping, problem-solving, social resource use, caregiving activity planning, and access to a web-based or mobile resource platform. Participants will be assessed at the start and at multiple points up to 12 months after their first cancer treatment. Researchers will measure changes in caregiver quality of life, resource use, strain, anxiety, depression, sleep quality, as well as patient quality of life and supportive care needs. The study involves questionnaires, interviews, and resource utilization tracking to monitor the effects of the intervention and supportive care over time.