Atasehir

Researchers are evaluating elacestrant compared to standard endocrine therapies in adults with node-positive, Estrogen Receptor-positive ER, HER2-negative early breast cancer who are at high risk of cancer returning. The study focuses on those who have had prior endocrine therapy and aims to measure how well elacestrant may prevent invasive breast cancer recurrence over five years. Participants are randomly assigned to receive either 345 mg of elacestrant daily for five years or continue their prior standard endocrine therapy, which may include an aromatase inhibitor anastrozole, letrozole, or exemestane or tamoxifen. The trial is open-label, meaning both participants and researchers know which treatment is given. During the study, participants will have regular assessments to monitor cancer recurrence, survival, side effects, and quality of life. Evaluations include questionnaires on health status and physical functioning at baseline, six months, and annually for up to five years. Safety is tracked through adverse event reporting up to five years plus 28 days. The total participation duration can last up to five years with ongoing monitoring and data collection.

Chronic non-specific neck pain is a common condition that negatively impacts pain levels, functional ability, and quality of life. Researchers are investigating how connective tissue massage and physical therapy methods, when combined with cervical and scapulothoracic stabilization exercises, affect pain, function, and endurance in adults aged 18 to 65 years. This randomized, double-blinded controlled trial compares three different approaches to treatment in this population. Participants are randomly assigned to one of three groups stabilization exercises alone, stabilization exercises plus connective tissue massage, or stabilization exercises plus electrotherapy modalities including infrared therapy, continuous ultrasound, and TENS. Each exercise session lasts 50 minutes and includes warm-up, stabilization exercises tailored to the individual, and cool-down, conducted face-to-face twice weekly for eight weeks. Participants also perform a daily one-hour home exercise program supported by illustrated brochures. During the study, participants will be assessed on pain using the Bournemouth Neck Questionnaire, disability via the Neck Disability Index, and endurance with the Deep Cervical Flexor Test. Secondary measures include quality of life, cervical range of motion, and scapular function tests. Outcomes are evaluated from enrollment through the end of the eight-week treatment period. The study aims to determine the added benefits of connective tissue massage and electrotherapy when combined with stabilization exercises.