Bagcilar

Researchers are studying patients aged 12 to 85 who experience dizziness and balance problems due to peripheral vestibular hypofunction. The purpose is to explore the relationship between the level of vestibular hypofunction and various vestibular and balance tests. Patients diagnosed through videonystagmography (VNG) by an ENT physician will be evaluated to understand how their vestibular function relates to clinical test results. Participants will provide demographic details including personal information and clinical history such as past illnesses, medication use, history of falls, and fears related to height or darkness. Diagnostic testing involves VNG to measure the degree of vestibular hypofunction. Vestibular and balance assessments like the Unterberger Test, Dynamic Visual Acuity, Head Thrust Test, Timed Balance Tests, and Static Posture Assessment will be conducted in a clinical setting. Throughout the study, which lasts about two months, participants will complete questionnaires such as the Dizziness Handicap Inventory and Tampa Kinesiophobia Scale to assess dizziness impact and fear of movement. Researchers will collect demographic data and perform videonystagmography and other vestibular tests regularly until study completion. The study monitors the connection between vestibular hypofunction severity and clinical test outcomes to improve understanding of this condition.

Researchers are evaluating the Turkish version of the General Sleep Disturbance Scale (GSDS-T) to determine its reliability and validity for assessing sleep issues in patients with multiple sclerosis (MS). While the GSDS-T has previously been tested with stroke patients, this study specifically focuses on its use with MS patients. The study involves 126 participants and aims to measure aspects such as difficulty falling asleep, waking during sleep, sleep quality, and daytime alertness. Participants will complete the GSDS-T, which consists of 21 questions designed to evaluate various sleep disturbances. To assess validity, the study will also use the Pittsburgh Sleep Quality Index (PSQI), a sleep quality questionnaire validated in Turkish. Both scales will be administered twice, with a 15-day interval between tests to check the consistency of responses over time. During the study, researchers will gather data on sleep disturbances and sleep quality at baseline. Participants will be evaluated using these questionnaires and monitored for test-retest reliability. The study focuses on adults aged 18 to 65 with MS, and data collection will help determine how well the GSDS-T works for this population.

Researchers are evaluating the effectiveness and safety of inavolisib combined with fulvestrant in adults with PIK3CA-mutated, hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer. This study focuses on patients who have previously been treated with cyclin-dependent kinase inhibitors and whose disease has progressed. The study is a Phase II, randomized, open-label trial designed to compare two dose levels of inavolisib when combined with fulvestrant. Participants will receive inavolisib and fulvestrant following specific schedules outlined in the study protocol. The trial involves comparing different doses of inavolisib combined with fulvestrant in this patient population. All treatments are administered as drugs, with dosing and administration details managed according to the study guidelines. During the study, researchers will monitor participants for objective response rate and treatment-emergent adverse events over approximately two years. Participants will undergo evaluations for disease status using standard criteria and will be assessed regularly for safety and treatment effects. The study requires participants to complete patient-reported outcomes and comply with all study procedures throughout their involvement.

Researchers are evaluating the Turkish version of the Situational Vertigo Questionnaire (SVQ), a tool used to assess dizziness symptoms often caused by vestibular problems and triggered by visual or environmental factors. This study is designed to adapt the SVQ to Turkish using a careful translation method and to test its validity and reliability in adults aged 18 and older who experience situational dizziness and can read Turkish. The goal is to create a reliable and culturally appropriate questionnaire to support clinical evaluations of dizziness in Turkish-speaking patients. The adaptation process involves translating the original SVQ into Turkish by bilingual translators, then back-translating it to English to ensure accuracy and equivalence. A committee will review all translations to finalize a preliminary Turkish version. This version will be pilot tested with 20 participants to check clarity. Afterwards, a larger group will complete the Turkish SVQ along with other dizziness-related scales to test how well the questionnaire performs. A subgroup will retake the SVQ after 7 days to assess test-retest reliability. Participants will fill out survey forms without undergoing any invasive procedures. They will complete the SVQ, Dizziness Handicap Inventory, Vertigo Symptom Scale, and Visual Analog Scale. The main outcome measured is the SVQ score at the start and again 7 to 14 days later for some participants. All data will be confidential. This study expects to provide a valid and reliable Turkish tool for measuring situational dizziness, helping healthcare providers better assess patients with vestibular conditions.