Karatay

Researchers are evaluating the effects of two opioids, fentanyl and remifentanil, on bowel recovery and pain after laparoscopic gallbladder surgery. Postoperative ileus, a delay in bowel function, is a common problem after abdominal surgery and can lead to longer hospital stays and increased costs. This trial aims to compare how these two drugs impact the time it takes for bowel function to return and how patients manage pain after surgery. Participants will be randomly assigned to receive either fentanyl or remifentanil during their surgery. Those in the fentanyl group will get an initial intravenous dose of 2 micrograms per kilogram followed by a continuous infusion of 1 to 2 micrograms per kilogram per hour. Those in the remifentanil group will receive a 1 microgram per kilogram IV dose followed by a continuous infusion of 0.1 to 1 microgram per kilogram per minute. Standard anesthesia drugs, including propofol, rocuronium, and sevoflurane, will be used for all patients. During the study, researchers will monitor the time until the first passage of gas as the main measure of bowel recovery, along with time to first bowel movement, ability to tolerate food, pain levels, need for additional pain medication, nausea and vomiting, stay times in recovery and hospital, and patient satisfaction. These outcomes will be tracked up to several days after surgery. The study includes 106 adults aged 18 to 65 who are healthy enough for elective surgery and will last through hospital discharge and follow-up assessments.