Kartal

Researchers are evaluating the safety and effectiveness of the LSALT peptide compared to a placebo in preventing or reducing acute kidney injury (AKI) in patients undergoing on-pump cardiac surgery. This phase 2, randomized, double-blind, multicenter study involves adults scheduled for non-emergent coronary or valve surgery requiring cardiopulmonary bypass. AKI is defined by specific kidney function changes within 7 days after surgery, including increases in serum creatinine or reduced urine output. Participants are randomly assigned to receive either the LSALT peptide or a placebo intravenously twice daily for five days, starting at least one hour before anesthesia. The LSALT peptide is designed to inhibit leukocyte recruitment without blocking enzymatic activity, potentially reducing side effects. Both groups will continue receiving standard care according to hospital guidelines throughout the study. Patients undergo screening up to 14 days before surgery. During treatment and through day 7, vital signs, urine output, kidney function tests, and biomarkers are monitored daily. Safety and adverse events are tracked through day 28. An independent board regularly reviews patient safety. The main outcome measured is the percentage of patients developing AKI within 7 days post-surgery, with follow-up assessments continuing until day 28.

Researchers are evaluating the Turkish version of the Barriers to Being Active Quiz (BBAQ-T), which was originally developed in English to identify obstacles to physical activity. This study aims to translate and culturally adapt the BBAQ into Turkish and assess its reliability and validity among healthy adults aged 18 to 35 years. The research addresses physical inactivity and related health knowledge and attitudes. The process includes a standardized back-translation method performed by two bilingual translators. A pilot study with 15 participants will assess the clarity of the language, relevance of concepts, and time needed to complete the quiz. Participants will complete the BBAQ-T twice, with a 5 to 7 day interval to evaluate test-retest reliability. Additional analyses will assess internal consistency and construct validity by comparing the BBAQ-T with other Turkish questionnaires on perceived barriers to physical activity and quality of life. A total of 210 healthy participants will take part in the study, which involves reading and writing in Turkish and following simple instructions. Researchers will monitor the quiz responses to measure barriers to physical activity and collect data on questionnaire reliability and validity. The study also evaluates participant adherence and cognitive function to ensure accurate completion. The overall participation duration includes initial and follow-up assessments within one week.