Maltepe

Researchers are evaluating the effects of NNC0487-0111 in adults with excess body weight and obstructive sleep apnea who are not using positive airway pressure treatment. This Phase 3 trial aims to assess the safety and effectiveness of this medication in helping participants lose weight and improve their sleep apnea. The study compares NNC0487-0111 with a placebo, which is an inactive treatment given by chance to participants. Participants receive weekly injections of either NNC0487-0111 or a matching placebo under the skin using pre-filled pen injectors applied to the thigh, abdomen, or upper arm. Both groups follow a reduced-calorie diet and increase physical activity during the study. The treatment period lasts for 80 weeks, during which researchers monitor changes in body weight and sleep apnea severity. Throughout the study, participants undergo regular assessments including body weight measurements and evaluation of the apnea-hypopnea index AHI to track sleep apnea severity. Additional tests measure sleep-related impairment, blood pressure, cholesterol levels, and blood sugar control. Safety is monitored by tracking any adverse events during the 84 weeks of the study. Participants progress is carefully followed to understand the impact of the treatment on weight and sleep apnea over time.

Researchers are evaluating the effectiveness and safety of NNC0487-0111 in adults with overweight or obesity who also have obstructive sleep apnoea and are being treated with positive airway pressure. This phase 3 study compares NNC0487-0111 to a placebo, which contains no active medicine, to see how well the treatment helps with weight loss and improvement in sleep apnoea symptoms. Participants will receive one of two dose levels of NNC0487-0111 or a matching placebo as weekly injections under the skin. These injections are given alongside a reduced-calorie diet and increased physical activity. The treatment is administered using pre-filled pen injectors to the thigh, abdomen, or upper arm, and the study lasts for 80 weeks. Throughout the trial, participants will be monitored regularly to assess changes in body weight, sleep apnoea severity measured by the apnoea-hypopnoea index AHI, and other health measures such as waist and neck circumference, blood pressure, cholesterol, blood sugar, and sleep quality scores. Safety is tracked by recording any treatment-related adverse events. The study runs until week 80, with follow-up continuing through week 84 to evaluate ongoing safety and effectiveness.

Parkinsons Disease PD is a movement disorder that affects balance, walking, and daily activities. This research aims to compare how well individuals with PD manage their own exercise plans independently using telerehabilitation versus following a supervised exercise program. The study focuses on improvements in quality of life, walking speed, physical function, and how well patients stick to their exercise routines. Participants will be randomly assigned to one of two groups for an 8-week program. One group will use a web-based system to perform exercises prescribed by a physical therapist at times they choose, twice a week. The other group will perform the same exercises twice a week via the web system but at scheduled times. Exercises include stretching, strengthening, balance, and neuromotor activities designed for home practice. During the study, participants cognitive and motor functions, balance, mobility, and quality of life will be assessed before and after the exercise program. They will keep an exercise diary and use a website to track their progress. Researchers will measure changes in motor impairment, exercise behavior, leg strength and endurance, walking speed, mobility, body position, and overall quality of life to understand the effects of managing exercise independently versus supervised sessions.

This research aims to explore how smartphone addiction affects posture and breathing control among healthy university students aged 18 to 35 years. Excessive smartphone use has been linked to changes in head and thoracic posture and musculoskeletal complaints, which may impact breathing patterns. Understanding these relationships may help clarify the physical effects of smartphone overuse in young adults. Participants will undergo an observational assessment involving questionnaires for smartphone addiction using the Smartphone Addiction Scale-Short Form and breathing control using the Self Evaluation of Breathing Questionnaire. Posture will be evaluated with the New York Posture Rating Chart. Participants will be grouped based on addiction status according to scale cutoffs to compare postural and respiratory outcomes. During the study, participants will provide demographic information, including age, sex, smoking status, and smartphone usage duration. Researchers will analyze data to determine if smartphone addiction independently predicts postural problems and how it relates to breathing control. This cross-sectional study will be conducted between April and September 2026 and aims to provide evidence on the musculoskeletal and respiratory consequences of excessive smartphone use.

Researchers are evaluating the Turkish version of the Barriers to Being Active Quiz BBAQ-T, a tool originally developed in English to identify barriers to physical activity. This study aims to translate and culturally adapt the BBAQ into Turkish and assess its reliability and validity among healthy adults. A total of 210 participants will be involved, mainly healthy university students aged 18 to 35 years. The study follows a standardized translation and back-translation method using bilingual translators. After a pilot study with 15 participants to check clarity and relevance, the full group will complete the BBAQ-T twice within 5 to 7 days to evaluate test-retest reliability. Researchers will analyze internal consistency and compare the BBAQ-T with related questionnaires, including the Self-Perceived Barriers for Physical Activity Questionnaire and the Short Form-12 SF-12. Participants will complete questionnaires assessing barriers to physical activity and related health concepts at baseline and a second time within a week. The study measures how consistent and valid the Turkish version of the quiz is by comparing results from different assessments. This observational study will last from May 20, 2025, to August 20, 2025, involving healthy adults who can read and write in Turkish and do not have conditions that might affect participation.