Mardin Merkez

Researchers are investigating the frequency of Neuronal Ceroid Lipofusinosis Type 2 CLN2 in children aged 2 to 6 years who have nonspecific neurological symptoms such as idiopathic seizures, speech disorders, and motor dysfunctions. This multicenter, non-drug screening study focuses on children without hypoxic ischemic encephalopathy, head trauma, or developmental brain anomalies, aiming to better understand the demographic and clinical features of those with possible CLN2 disease. Children first undergo assessments including recording demographic and medical history, seizure frequency, cognitive and language development evaluations, physical exams assessing muscle strength, gait, and coordination, as well as neurological evaluations using EEG and MRI scans. Those showing specific signs like speech disorder with seizures, movement problems, particular EEG responses, or MRI findings will have blood samples taken to measure Tripeptidyl Peptidase 1 enzyme levels. If enzyme activity is low, genetic testing is performed to investigate CLN2 disease. Participants are involved for up to one year during which various clinical, neurological, and imaging evaluations are done. Blood samples are collected for enzyme and genetic analyses. The main outcome measured is the frequency of CLN2 disease in this group. The study tracks each childs symptoms, neurological findings, and imaging results to better identify and understand CLN2 in children with these symptoms.

This research aims to evaluate the safety, performance, and usability of several Occlutech accessory medical devices used in heart disease treatment. These devices include the Occlutech Delivery Set ODS, Occlutech Pistol Pusher OPP, Occlutech Occlusions-Pusher OOP, and Occlutech Sizing Balloon OSB. The study is international, multicenter, non-randomized, and non-invasive, focusing on catheter-based implantation procedures for cardiac implants. The study involves physicians experienced in cardiac catheterization using these accessories during implantation procedures. Investigators complete detailed surveys to assess each devices safety, including success of implantation, adverse events during or after the procedure, user harm, and any device deficiencies. The surveys also evaluate the performance, usability, and compatibility of these accessories with other devices. Subjects receive treatment following standard clinical routines and specific instructions for use. Participants who have undergone implantation with an Occlutech accessory and cardiac implant are included. Researchers monitor safety events and assess device performance and usability over a 6-month period. Data is collected via investigator questionnaires, focusing on implantation outcomes and any related complications. The total participation duration varies depending on individual follow-up but includes at least 6 months of monitoring for safety and performance.

This research aims to evaluate whether a mixed reality-based training program can effectively teach midwifery students to assess cervical effacement and dilation. It also explores how this training impacts students cognitive load, sense of presence, and their professional perception of midwifery. The study compares students receiving mixed reality training with those undergoing traditional instruction. Participants are randomly assigned to either a mixed reality training group or a standard education group. The mixed reality group interacts with 3D virtual cervical models and practices assessments in a safe, repeatable environment, followed by virtual patient scenarios. Afterwards, they perform vaginal examinations on five pregnant women under supervision. The control group receives traditional theoretical instruction before performing similar clinical assessments. Both groups complete scales measuring cognitive load, presence, and professional perception. Throughout the study, participants accuracy in measuring cervical dilation and effacement is evaluated over four months. Cognitive load and midwifery professional perception are assessed at four months, while sense of presence is measured immediately after the mixed reality training. All clinical assessments happen during supervised practice on pregnant women in real settings. The study runs from October 2025 to February 2026, allowing thorough evaluation of training effects on practical skills and perceptions.

Pes planus is a common foot condition where the arch of the foot collapses, affecting balance and posture. Researchers are investigating whether adding Basic Body Awareness Therapy BBAT, a physiotherapy method that improves movement and body awareness, to Short Foot Exercises SFE can better improve foot arch height, foot function, gait, balance, proprioception, and plantar sensation in adults with flexible pes planus. This randomized controlled trial will include 50 participants aged 18 to 45 years. Participants will be randomly assigned to one of two groups one group will receive BBAT combined with SFE, and the other group will perform SFE only. Both interventions will last eight weeks, with supervised sessions twice a week. BBAT sessions last 45 minutes and focus on postural control, motor coordination, and balance, progressing from lying down to walking. SFE sessions last about 20 minutes and progress through sitting to functional activities. Participants will also perform home exercises and adherence will be monitored online. Participants will be assessed at three times before starting the intervention, immediately after the eight-week intervention, and two months later. Researchers will measure foot arch height using the Navicular Drop Test, balance, proprioception, light touch sensation, foot pain and disability, gait performance, and body awareness. This study aims to provide new insights into improving treatment for pes planus by combining sensory and exercise approaches.