Mardin Merkez

This research aims to investigate the frequency of Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) in children aged 2 to 6 who exhibit nonspecific neurological symptoms such as idiopathic seizures, speech disorders, and motor dysfunctions. The study targets children without hypoxic ischemic encephalopathy, head trauma, or developmental brain anomalies who visit Pediatric Metabolism, Neurology, and Developmental Pediatrics clinics over a 12-month enrollment period. It is a multicenter, non-drug screening study designed to better understand CLN2 disease among this population. During the study, demographic data, medical and family history will be collected at the first visit. Assessments will include seizure frequency, cognitive and language development evaluations, physical exams focusing on muscle strength, gait, and coordination, as well as neurological tests such as EEG and MRI scans. Children showing specific neurological signs or imaging findings will have blood samples taken for Tripeptidyl Peptidase 1 enzyme measurement. Those with low enzyme activity will undergo genetic testing to investigate CLN2 disease. Participants will be monitored for disease frequency over one year. Researchers will measure clinical and demographic characteristics including speech impairment, motor symptoms, EEG responses, and brain imaging changes. Safety monitoring includes obtaining informed consent and following up on enzyme and genetic test results. Total participation spans from initial screening through diagnostic testing and data collection during the 12-month study period.

This research aims to evaluate the safety, performance, and usability of Occlutech accessory medical devices used in cardiac implant procedures. It is an international, multicenter, non-randomized, non-invasive registry study focusing on devices such as the Occlutech Delivery Set (ODS), Occlutech Pistol Pusher (OPP), Occlutech Occlusions-Pusher (OOP), and Occlutech Sizing Balloon (OSB). The study collects data through investigator-completed surveys to monitor device-related outcomes during and after catheter-based cardiac implant interventions. The study involves the use of the specified Occlutech accessory devices by experienced physicians skilled in cardiac catheterization and interventional operations. Investigators complete detailed questionnaires assessing the success of implantation procedures, any adverse events occurring during or after the procedures, user harm related to the accessories, and any device deficiencies. The surveys also evaluate performance, usability, and compatibility of the accessories with other devices. Participants are treated following the implants' and accessories' instructions for use and standard clinical practice. Participants' involvement includes undergoing implantation procedures with these accessory devices, after which investigators collect data via surveys. The study monitors safety events over six months, including any adverse outcomes linked to the accessories or procedures. The collected information helps assess the devices' safety profile and practical use in real-world clinical settings. The total duration of monitoring and follow-up is six months per participant to capture both immediate and longer-term effects.

This research aims to evaluate whether a mixed reality-based training program helps midwifery students learn how to assess cervical effacement and dilation more effectively. The study also investigates how this technology affects students' mental effort, feeling of being present in the learning environment, and their professional view of midwifery. Researchers want to find out if students trained with mixed reality perform better in real clinical assessments compared to those trained traditionally. Participants will be divided into two groups: one receiving mixed reality training and the other receiving standard theoretical education. The mixed reality group will practice with 3D virtual cervical models and complete vaginal examinations on 10 virtual patients, with the system automatically evaluating their accuracy. After this, they will examine five pregnant women in clinical settings under supervision. The control group will receive traditional instruction, complete similar scales, and also examine five pregnant women under supervision. During the study, all participants will complete scales measuring cognitive load, sense of presence, and professional perception. They will perform cervical assessments on five real pregnant women, and researchers will monitor and compare the accuracy of their measurements. The main outcomes measured are the accuracy of cervical dilation and effacement assessments after four months. This study involves female midwifery students aged between 1.5 years (interpreted as 18 months) and 35 years and includes pregnant women in the first stage of labor without complications.

Researchers are studying the effects of music on first-time mothers who have undergone a cesarean section. The study focuses on how listening to music may influence pain levels, anxiety, and breastfeeding success shortly after delivery. This research aims to better understand how behavioral interventions like music could support women's recovery and comfort after cesarean birth. Participants will listen to music as the behavioral intervention being evaluated. This approach is intended to assess the impact of music during the immediate postpartum period following cesarean section delivery. The study does not mention additional treatments or comparison groups. During the study, women will be assessed within the first hour after birth for levels of pain, state anxiety, and success in breastfeeding. Researchers will monitor these outcomes to evaluate the effects of music listening. The total participation duration and further follow-up details are not specified.

Researchers are evaluating whether adding Basic Body Awareness Therapy (BBAT) to Short Foot Exercises (SFE) can improve foot arch height, balance, body awareness, and sensory function in adults with flexible pes planus, a condition where the foot arch collapses affecting posture and stability. This randomized controlled trial will include 50 participants aged 18 to 45 years, divided into two groups: one receiving BBAT combined with SFE, and a control group receiving SFE alone. The study aims to explore both somatic and sensory benefits of BBAT as a complementary treatment. Participants in the BBAT group will attend 45-minute therapy sessions twice weekly for eight weeks in small groups led by certified physiotherapists. These sessions focus on postural control, motor coordination, balance, and functional movements progressing through various positions from lying down to walking. Following each BBAT session, participants will perform SFE. The control group will also perform SFE twice weekly under supervision and additionally at home five days per week for eight weeks, with exercises progressing from sitting to functional activities. Assessments will be made at three points: before starting the interventions, immediately after the eight-week period, and two months later. Researchers will measure foot arch function using the Navicular Drop Test, dynamic balance, proprioception, and light touch sensation. Participants' adherence to exercises will be monitored online. This study seeks to provide new insights into holistic physiotherapy approaches for pes planus and improve clinical care options.