Mugla Merkez

Researchers are evaluating AZD0780, an oral PCSK9 inhibitor, in a phase 3, randomized, placebo-controlled study to see if it can reduce the risk of major adverse cardiovascular events (MACE-PLUS) in adults with established atherosclerotic cardiovascular disease (ASCVD) or those at high risk for a first ASCVD event. The study compares AZD0780 to a placebo and monitors participants from randomization until the primary analysis censoring date, followed by a final study closure visit. Participants will be randomly assigned to receive either oral AZD0780 or an oral placebo once daily. The treatment period lasts until the primary analysis censoring date, after which a study closure visit will occur. The study is event-driven and designed to assess the time to the first major cardiovascular event during treatment. During the study, participants will be closely monitored with various assessments to evaluate cardiovascular outcomes and safety over approximately 54 months. Researchers will track the time to first event of any component of MACE-PLUS and collect data to assess the effect of AZD0780 compared to placebo. The study includes regular visits and evaluations to ensure participant safety and adherence to treatment.

Chronic neck pain is a common musculoskeletal issue that can negatively affect daily function and quality of life. This research aims to compare the effectiveness of three types of exercise training—craniocervical flexion, static isometric, and dynamic isometric exercises—when combined with a conventional physiotherapy program in adults with chronic neck pain lasting more than three months. Participants will be assigned to one of four groups: craniocervical flexion exercise training using a pressure biofeedback device, dynamic isometric exercise training with elastic resistance bands, static isometric exercise training involving maximal effort neck exercises, or a conventional treatment group receiving electrotherapy including TENS, ultrasound, and hot packs along with chin tuck exercises. All treatments will occur three times a week for eight weeks with progressive intensity tailored to each participant. Throughout the study, researchers will assess pain, disability, posture, muscle strength and endurance, range of motion, and body awareness at the beginning and end of the eight-week period. Electrotherapy treatments involve specific parameters such as TENS for 20 minutes, ultrasound for 5 minutes, and hot packs for 10 minutes. Outcome measures focus on pain and disability after eight weeks, with careful monitoring of each participant's progress during the program.

Researchers are investigating whether coughing is a factor that may contribute to the development or worsening of hemorrhoids. The study will examine symptoms, duration, and severity of cough in patients diagnosed with hemorrhoidal disease at the General Surgery Outpatient Clinic of Mu
1fla Education and Research Hospital. Hemorrhoids will be assessed through rectal exams and graded by mucosal prolapse. The study aims to explore the relationship between cough characteristics and hemorrhoid severity, as well as examine links with chest diseases and smoking history. Patients newly diagnosed with hemorrhoids between March and June 2025 will undergo physical exams and assessments including height and weight measurement, the Leicester Cough Questionnaire, and the Cough Visual Analog Scale. Cough duration will be categorized as acute or chronic, and information on timing, comorbidities, and smoking status will be collected. Patients with cough will be referred for further chest disease evaluation. Data on hemorrhoid stage, symptoms, comorbidities, and lifestyle factors will also be gathered. Participants will provide demographic and health information, complete questionnaires, and undergo clinical evaluations. Researchers will measure cough severity and frequency along with hemorrhoid grading to analyze their relationship. The primary outcome is the Leicester Cough Questionnaire score on day 1. The study will also consider other factors like chest diseases and smoking. This observational study will use data from at least 134 patients to identify potential links and improve understanding of hemorrhoid causes and management.

Researchers are evaluating the effects of Reiki and self-acupressure on functionality and quality of life in patients with multiple sclerosis. Reiki is a complementary energy-based therapy originating from Japan, believed to influence energy flow through seven main chakra centers along the spine. It has been studied for its impact on symptoms like pain, depression, insomnia, and fatigue. The study aims to compare these two methods as supportive treatments for people living with multiple sclerosis. Participants will receive either Reiki or self-acupressure treatments. Reiki sessions involve the practitioner placing their hands on or near the head, neck, chest, abdomen, and groin for several minutes, with treatment lasting between 30 to 90 minutes. During treatment, patients remain clothed and reclined comfortably. Self-acupressure involves participants applying pressure to specific points themselves. Both interventions are behavioral and non-invasive. Throughout the study, participants' quality of life and functional abilities will be assessed over a 4-week period using established measures for multiple sclerosis. The study will monitor any changes in symptoms and overall well-being. Participants must meet certain health and lifestyle criteria for inclusion and will be regularly evaluated to ensure safety and adherence. The study duration and assessments are designed to capture the short-term effects of these treatments.

Researchers are evaluating the use of a pain diary to assess early postoperative pain in patients undergoing elective laparoscopic cholecystectomy. This randomized controlled trial aims to compare the pain diary method with routine pain assessment using the Visual Analog Scale (VAS) without adding any new pain medications. The goal is to enhance patient involvement in pain evaluation after surgery. Participants are randomly assigned to one of two groups: the intervention group uses a patient-completed pain diary to record pain intensity at rest and during movement at specific times after surgery, while the control group receives standard pain assessment with VAS at the same time points. The pain diary is introduced before surgery with instructions on how to complete it. Both groups follow a postoperative pain management protocol that includes scheduled medications and non-drug pain control measures. To avoid cross-contamination, patients in each group stay in separate hospital rooms. During the first 48 hours after surgery, pain intensity is measured multiple times at 2, 4, 6, 12, 16, 20, 24, 32, and 48 hours post-operation using standardized tools. Additional pain-related assessments are also conducted. Researchers monitor patient adherence to the pain diary and compare pain levels recorded by both methods. The study focuses on the early postoperative period with continuous evaluation to understand pain management and patient participation better.

Researchers are studying the effect of remote ischemic preconditioning (RIPC) on heart protection in patients with type 2 diabetes undergoing planned coronary artery bypass graft (CABG) surgery. CABG surgery can cause heart injury around the time of surgery, especially in diabetic patients who are at higher risk. RIPC is a simple, non-invasive, and low-cost method that may help reduce heart damage by making the heart more tolerant to reduced blood flow through brief cycles of limb blood flow restriction. In this randomized, double-blind trial, 60 patients aged 40 to 85 years with type 2 diabetes scheduled for isolated CABG surgery will be assigned to either receive RIPC or standard care. The RIPC procedure involves inflating and deflating a blood pressure cuff on the upper arm five times for 5 minutes each, performed under general anesthesia before the surgical incision. No medications are used during the procedure. The study compares this method against usual care without RIPC. Participants will have blood tests measuring high-sensitivity troponin T at 24, 48, and 72 hours after surgery to assess heart injury. Other outcomes include kidney function, use of heart support medications, and length of stay in the intensive care unit and hospital. These measures will help researchers understand if RIPC offers heart protection during surgery in diabetic patients and track their recovery and safety over the hospital stay.

Researchers are investigating the effects of adding Rubus sanctus root extract, known for its antioxidant properties, to the regular diet of patients with Graves' disease. This study is a single-blind, randomized, experimental clinical trial that aims to assess whether this supplement influences the progression of Graves' disease. Graves' disease is an autoimmune condition causing an overactive thyroid, and oxidative stress plays a role in autoimmune diseases, making antioxidant-rich supplements a potential supportive treatment. Participants are divided into two groups: an experimental group receiving 5 grams of Rubus sanctus root extract as a tea daily for 8 weeks, and a control group consuming black tea daily for the same period. Both groups continue their usual diet and any necessary pharmacological treatments. The root extract tea is prepared by steeping the extract in hot water, and participants are provided with equipment to ensure proper preparation. Monthly routine tests and thyroid ultrasounds are conducted before and after the intervention to monitor changes. Throughout the study, participants will undergo regular blood tests to measure thyroid hormones and autoimmune markers, along with liver function tests. Anthropometric measurements including body composition, neck, waist, and hip circumference, and height are taken at baseline and after 8 weeks. Weekly check-ins help monitor adherence and potential side effects. The main outcomes measured are the effect of Rubus sanctus root on thyroid hormone levels, autoimmune disease markers, and anatomical changes in the thyroid gland over the 8-week period.

Researchers are investigating the frequency of Alpha-1 Antitrypsin Deficiency (AATD), a genetic condition that causes low levels of a lung-protecting protein, in patients experiencing shortness of breath and airway obstruction. This inherited disorder can lead to lung diseases like emphysema, especially among smokers. The study focuses on patients visiting a pulmonary outpatient clinic who show signs of airway obstruction on breathing tests and aims to better detect AATD to improve diagnosis and treatment options. Participants will be divided into two groups based on their breathing test results: those with airway obstruction and those without. Blood samples will be taken for analysis of AAT protein levels and for genetic testing of common mutations causing AATD. The blood for protein levels will come from routine clinical samples, while genetic testing will use a small finger prick sample collected on special filter paper. Laboratory staff analyzing the samples will not know the patients' group assignments to ensure unbiased results. During the study, participants will undergo clinical assessments including a questionnaire on breathlessness severity and smoking history. Spirometry equipment will be regularly calibrated to assure accurate lung function testing. Researchers will compare AAT levels and genetic results across groups and examine the relationship between breathlessness and AAT status. Data will be carefully recorded and analyzed to identify any links between AATD and airway obstruction, supporting future targeted interventions. The total involvement includes initial screening, blood sampling, and data collection during outpatient visits.

Researchers are evaluating the effect of balcinrenone/dapagliflozin compared with dapagliflozin alone on cardiovascular death and heart failure events in patients with chronic heart failure and impaired kidney function who recently experienced a heart failure event. This is a Phase III, international, randomized, double-blind, parallel-group, active-controlled study involving approximately 700 sites in about 40 countries. Participants will be randomly assigned in a 1:1:1 ratio to receive one of three treatments once daily: a capsule of balcinrenone/dapagliflozin 15 mg/10 mg with a placebo tablet, a capsule of balcinrenone/dapagliflozin 40 mg/10 mg with a placebo tablet, or a dapagliflozin 10 mg tablet with a placebo capsule. The study is event-driven, with an estimated average duration of 22 months that includes a screening period, a 20-month blinded treatment phase, and a one-month follow-up on open-label dapagliflozin. During the study, participants will be monitored for the time to first occurrence of cardiovascular death, heart failure hospitalization, or heart failure events without hospitalization over approximately 38 months. Assessments include clinical evaluations, laboratory tests, and safety monitoring throughout the study and follow-up period to track treatment effects and patient outcomes.

This research focuses on patients diagnosed with subacromial impingement syndrome, a common cause of shoulder pain. The study evaluates the relationship between shoulder functional tests and ultrasound measurements in patients who visit the Physical Medicine and Rehabilitation outpatient clinic at Mu
1fla Training and Research Hospital. Eligible patients are adults aged 18 to 70 years who test positive for subacromial impingement through clinical exams such as Neer's test, Hawkins Kennedy, and supraspinatus palpation test. On the study day, researchers collect demographic information and assess shoulder function using the Disabilities of the Arm, Shoulder and Hand (DASH) and Constant Murley scores. A radiologist with four years of musculoskeletal ultrasound experience performs ultrasound examinations using a SiemensAE V8 machine with an LA2-14A probe. Ultrasound measurements include subacromial bursa thickness, supraspinatus tendon thickness, acromiohumeral distance, and the ratio of supraspinatus tendon thickness to acromiohumeral distance, all performed with the patient in a modified Crass position. Participants provide data once during the study visit, including functional scores and ultrasound measurements. Researchers analyze these results to explore how shoulder functional tests relate to ultrasound parameters, aiming to better understand the characteristics of subacromial impingement syndrome. The primary outcomes measured on the study day are subacromial bursa thickness, supraspinatus tendon thickness, and acromiohumeral distance.