Zaporizhzhia

Cervical cancer, mainly caused by persistent infection with high-risk human papillomavirus (HPV), is a leading cause of cancer deaths among women worldwide. Researchers are evaluating an HPV-based cervical cancer screening program using self-sampling in Zaporizhzhia, Ukraine, a region affected by armed conflict. The study aims to improve access to screening during conflict by offering a modern, simple approach that can adapt to challenges like disrupted health services and population displacement. Participants receive an HPV self-sampling kit containing a sterile vaginal swab and collection tube with illustrated instructions for home or clinic use. Samples are returned free of charge to clinics or community volunteers and tested in accredited Ukrainian molecular laboratories using validated PCR assays. HPV-positive women receive follow-up care according to national guidelines, including referral to gynecologists for further tests and treatment if needed. HPV-negative women are reassured and advised on future screening intervals. Women aged 30 to 60 years in Zaporizhzhia who have not had a recent negative HPV test are invited to participate. The study tracks uptake of self-sampling within 12 weeks of kit receipt and evaluates implementation outcomes such as acceptability, feasibility, and sustainability. Data collection includes patient surveys, healthcare provider interviews, and registry monitoring. The project is conducted in collaboration with local and international partners to develop a safe, effective, and scalable cervical cancer screening model for conflict-affected settings.