Chipping Norton

Researchers are conducting a multi-center, global, randomized, double-blind, placebo-controlled Phase 2b trial to evaluate the effectiveness, safety, and tolerability of IMVT-1402 in adults with Graves' disease who remain hyperthyroid despite antithyroid drug treatment. The study focuses on participants aged 18 to 75 years who have this diagnosis and are still experiencing hyperthyroidism. Participants will receive either IMVT-1402 or a placebo for 26 weeks. The study includes two dosing regimens of IMVT-1402: Dose 1 administered for 26 weeks and Dose 2 also administered for 26 weeks. The placebo group will receive treatment for the same duration. The treatments are given as drugs, and the study is designed to keep both participants and researchers unaware of which treatment is assigned. During the study, researchers will monitor participants to see how many achieve normal thyroid function (euthyroid) and remain off antithyroid drugs by Week 26. Participants will be assessed regularly to evaluate safety, tolerability, and treatment effects. The involvement includes following the assigned treatment and attending scheduled visits for evaluations. The total participation time corresponds with the 26-week treatment period.

Researchers are studying advanced pelvic cancers, which are complex and require treatments like radiotherapy, chemotherapy, and extensive surgery involving multiple pelvic organs. These surgeries often result in complications related to the empty pelvis syndrome and perineal wound closure, affecting recovery and quality of life. The study aims to evaluate how different reconstruction methods after surgery influence complication rates, patient quality of life, and healthcare costs, to improve decision-making for patients and doctors. The study has three parts: first, maintaining a database of patients undergoing colorectal surgeries including pelvic exenteration and abdominoperineal excision, collecting detailed clinical data, imaging, complications, and patient outcomes. Second, a national prospective study where patients undergoing these surgeries complete quality of life and financial impact questionnaires before surgery and at 3, 6, and 12 months after surgery. The surgical reconstruction method is chosen by the surgeon. Third, a qualitative study involving interviews with patients at 3 and 12 months post-surgery to explore experiences and quality of life in depth. Participants provide clinical information and complete various patient-reported outcome measures including quality of life and financial toxicity questionnaires. Researchers monitor surgical details, complications, healthcare use, and survival. Follow-ups involve telephone or email contacts for questionnaire completion. Data analysis includes statistical modeling and health economic evaluation. The qualitative interviews are recorded, transcribed, and analyzed to identify themes over time. The study lasts up to 12 months of follow-up after surgery, with patient involvement throughout.