Harpenden

Researchers are exploring the benefits of personalised music for people living with mild to moderate dementia, particularly those in care homes. This study aims to develop and test methods for quickly creating and delivering personalised music playlists, and to assess how individuals respond to this music. The study also includes a sub-study using brain imaging to understand the effects of music on behavioural and psychological symptoms in dementia, and an extension inviting families to use a WebApp to create playlists for loved ones living with dementia in the community. Participants will have personalised playlists created based on their musical preferences collected from themselves and their carers. They will attend a music listening session where responses to short excerpts of music are monitored using wrist-worn devices, video recordings, and observations of movements and facial expressions. The refined playlists will then be used in ongoing listening sessions, with delivery methods such as wireless headphones or smart speakers tested for ease of use and effectiveness. The study also involves focus groups and interviews with carers and care home staff to gather feedback on the impact and delivery of personalised music. Throughout the study, participants and carers will complete assessments of behavioural and psychological symptoms and quality of life at intervals. Emotional responses to music will be analysed using automated facial expression analysis and physiological monitoring. The study will observe how personalised music affects residents over time, including during difficult care moments. Participation involves consent procedures, training for carers and staff, and ongoing qualitative and quantitative data collection over several months to develop and refine methods for future larger-scale studies.

Researchers are collecting real-world data on patients undergoing rotator cuff repair using the REGENETEN Bioinductive Implant System. This prospective, single-arm, multicenter registry involves up to 50 centers across the United Kingdom, Europe, and Australia, aiming to enroll up to 400 patients. The study focuses on evaluating clinical and health economic outcomes after surgery for rotator cuff injuries. Participants receive arthroscopic rotator cuff repair surgery augmented with the REGENETEN Bioinductive Implant, a device designed to manage and protect tendon injuries without substantial tendon tissue loss. Patients are treated according to standard medical care, and the study gathers data on their recovery and outcomes over time. Participants will be monitored up to two years after surgery with regular assessments including quality of life, arm and shoulder function, pain levels, and shoulder-specific scores at baseline, 2 weeks, 6 weeks, 3 months, 6 months, 12 months, and 24 months. Additional data on retear rates, postoperative recovery, sling use, mobilization time, and return to work are also collected. The study provides long-term insight into patient progress following the use of the implant.