Agra

Researchers are studying the safety and performance of Motiva Implants®, silicone gel-filled breast implants used for breast augmentation and revision procedures. This prospective, non-randomized, multicenter study collects data before surgery, during the operation, and annually for up to 10 years. The study also compares the incidence of connective tissue disease signs and symptoms in participants with Motiva implants to a control group undergoing other aesthetic surgeries. Participants receive either Motiva Implants® during breast augmentation or revision surgeries or undergo other aesthetic procedures like liposuction, rhinoplasty, or face-lifts in the control group. The study includes monitoring of implant performance and safety, with some participants possibly undergoing CT, ultrasound, or MRI evaluations if recommended. Participants agree to return explanted devices to the sponsor, and they must follow all study requirements throughout the study period. During the 10 years of follow-up, participants have yearly assessments to gather operative and postoperative data. Researchers evaluate safety and effectiveness, tracking any signs of connective tissue diseases and other outcomes related to the implants or aesthetic procedures. The study monitors participant health and implant status through imaging and clinical evaluations to provide long-term safety information.

Researchers are evaluating a prescribed sub-symptomatic adaptable exercise treatment (SAET) as a potential way to help active duty service members with mild traumatic brain injury (mTBI) who have ongoing symptoms. The goal is to see if SAET can reduce symptoms, improve mental health, enhance physiological functioning, and help participants return to duty. This study compares SAET to a stretching control group to determine which is more effective at reducing neurobehavioral symptoms and improving cognitive and physical performance. Participants will be randomly assigned to either the SAET group or the stretching control group (SCG). SAET workouts last about 50 minutes and include stretching and warm-up, light to moderate aerobic exercise, a series of resistance and stability exercises with alternatives to accommodate limitations or preferences, and mobility or cool-down exercises. The SCG also involves 50-60 minute sessions focusing on stretching without raising heart rate, with modifications available for difficulty. These treatments are designed to be adaptable to various clinical settings. During the study, participants will undergo assessments of neurobehavioral symptoms, cognitive function, physiological changes such as blood flow and cardiovascular health, and military performance including locomotion and physical fitness tests. Researchers will track changes from before treatment through immediate and three months post-treatment to evaluate improvements. The total participation duration covers these assessments alongside the exercise program to monitor safety and effectiveness.