Menlo Park

Researchers are studying adults living with HIV who are taking or have taken long-acting injectable therapy to manage their condition. This observational study aims to understand how HIV affects the lives of these patients by collecting detailed information through an online questionnaire. The study focuses on various aspects including health, well-being, and social factors related to living with HIV. Participants complete an online questionnaire that gathers data on demographics, daily activities, HIV diagnosis and status, healthcare use and satisfaction, antiretroviral therapy, other medical conditions, substance use, and sexual practices. The study includes people currently receiving long-acting injectable therapy either through ViiV-sponsored trials or prescribed by their healthcare provider, as well as those who have previously received at least three injections of this therapy. Participants will be assessed at the start and throughout the study, which averages 12 months, on many factors including loneliness, quality of life, cognitive function, social well-being, depression, anxiety, sleep quality, alcohol use, stigma, resilience, interpersonal support, medication adherence, and frailty. The study collects baseline data and tracks these outcomes over time to better understand the impact of long-acting injectable therapy for HIV.

Researchers are evaluating the safety, feasibility, effectiveness, and lasting effects of non-invasive electrical vestibular stimulation (EVS) on balance and walking ability in healthy adults aged 18 to 100 years. This study focuses on improving balance and gait by stimulating the vestibular system, which helps maintain stability and coordination. The research also explores whether EVS-induced changes in vestibular function are linked to improvements in cognition and potential benefits for occasional headaches. The study involves 18 treatment sessions over 5 to 6 weeks where participants receive subthreshold wideband stochastic EVS through electrodes placed behind the ears and at the back of the neck. During each session, participants switch between sitting and standing on different surfaces with eyes open or closed while receiving stimulation. A sham comparator group receives no current during EVS treatment. Follow-up assessments occur at 3 weeks, 6 weeks, 3 months, and 6 months after treatment to evaluate lasting effects. Participants undergo various balance and gait tests using wearable sensors, smartphone app-based assessments, clinician-administered functional gait evaluations, and cognitive tests. Researchers measure outcomes such as postural sway, sensory integration, walking speed, step length, and trajectory before, during, and up to 6 months after treatment. Questionnaires assess headaches, cognition, dizziness, and physical activity. Safety and adverse events are monitored throughout the study.