Solana Beach

This research aims to evaluate the effectiveness and safety of IPN10200 compared to a placebo in improving the appearance of moderate to severe glabellar lines, which are wrinkle-like lines between the eyebrows. These lines can become more noticeable with age or repeated facial expressions and may affect a person's appearance and confidence. The study is a Phase III trial involving adult participants with these moderate to severe glabellar lines. Participants will receive a single injection of either IPN10200, a lyophilised powder for solution injected into several sites across the glabellar region, or a placebo injection containing excipients without the active substance. The study consists of three periods: a screening period lasting up to 20 days to determine eligibility; a treatment period on Day 1 when the injection is given; and a follow-up period lasting 52 weeks with regular visits and one telephone call to monitor participants' health. During the study, participants will undergo various health assessments including blood sampling, physical exams, clinical evaluations, and electrocardiograms. They will also complete questionnaires and keep diaries to record their experience. The main outcome measured is the percentage of participants responding to treatment four weeks after baseline. Participants may stay in the study for up to 55 weeks and can withdraw consent at any time.