Berwyn

Researchers are evaluating the TeamBirth quality improvement training program aimed at improving shared decision-making during labor and delivery. This study focuses on reducing cesarean births among first-time mothers with term, singleton, vertex pregnancies, especially Black birthing people. It also aims to enhance patient experience and promote respectful care through patient participation in decision-making on labor units. The study compares the TeamBirth intervention, which uses a train-the-trainer model to support shared decision-making huddles, against usual care practices. Participants will be randomly assigned to either the TeamBirth program or usual care. The evaluation measures outcomes before and after TeamBirth implementation over specific timeframes. Participants will be monitored for cesarean birth rates and shared decision-making levels six months before and three months after the intervention starts. Patient experience is also assessed during these periods. The study includes English or Spanish speaking individuals aged 18 or older who gave birth after laboring. Outcomes focus on both overall and Black birthing people, with follow-up planned until July 2029.

This research focuses on people with psychosis linked to Alzheimers Disease who have completed earlier studies CN012-0026, CN012-0027, or CN012-0056. It is a Phase 3 global, multicenter, open-label extension study lasting 52 weeks that aims to evaluate the long-term safety and tolerability of KarXT in this population. Participants will receive KarXT capsules containing Xanomeline and Trospium Chloride. The study includes various dosing levels ranging from 202 mg to 66.76.67 mg taken three times daily. This open-label extension follows completion of previous studies and continues for up to 54 weeks from the initial dose, including a 14-day safety follow-up after the final dose. During the study, participants will be monitored for treatment-emergent adverse events and serious adverse events. Safety assessments include clinical evaluations throughout the treatment and 14 days after the last dose. The total participation time is approximately one year, allowing researchers to understand long-term effects of KarXT in this group.