Denton

Researchers are evaluating the LINKED-HEARTS Program, a multi-level project aimed at adults with uncontrolled hypertension (blood pressure 140/90 mm Hg or higher) who also have type 2 diabetes or chronic kidney disease. This program seeks to improve control of blood pressure, blood sugar, and kidney function by linking home blood pressure monitoring with a telemonitoring platform called Sphygmo. The study involves 600 adults across 16 community health centers or primary care practices serving high-risk populations. The study has two groups: one receiving enhanced usual care, where patients get Omron 10 series home blood pressure monitors and are managed by their primary care clinicians as usual; and the other receiving the LINKED-HEARTS intervention. This intervention integrates home blood pressure telemonitoring via the Sphygmo app, visits from community health workers for education and lifestyle counseling, and pharmacist collaboration through telehealth to optimize medication therapy and work with payors to ensure access to necessary treatments. Participants will be followed for 12 months, during which their blood pressure control is assessed as the primary outcome. The study includes monitoring through home blood pressure devices, telemonitoring apps, and healthcare provider collaboration. Researchers will track blood pressure control rates and support participants in managing their chronic conditions. The study aims to improve clinical outcomes and reduce health disparities in this high-risk group.

Researchers are evaluating a peer-led behavioral intervention to improve medication adherence for opioid use disorder (MOUD) and reduce polysubstance use in patients with opioid use disorder (OUD) living in underserved rural areas. This study focuses on a behavioral activation (BA) approach delivered by trained peer recovery specialists to enhance treatment retention and address the challenges of polysubstance and stimulant use. The trial is a hybrid Type-1 effectiveness-implementation randomized controlled trial comparing the peer-led intervention to treatment as usual over a twelve-month period. The intervention, called Peer Activate, includes about six weekly core sessions lasting 30 minutes to 1 hour, followed by up to six optional booster sessions. During these sessions, participants learn behavioral activation and problem-solving skills aimed at overcoming barriers to medication adherence and engaging in rewarding, substance-free activities to support recovery and reduce polysubstance use. The comparison group receives enhanced treatment as usual, which includes facilitated referrals and general peer recovery specialist support. Participants will be assessed for polysubstance use through urine tests and self-report from the start of the study through a six-month follow-up. Researchers will also evaluate treatment retention over twelve months, as well as the feasibility, acceptability, and fidelity of the peer-led intervention. The total study duration includes baseline assessment and follow-up periods, with outcomes measured to assess effectiveness and implementation in telemedicine-based OUD treatment in rural settings.