Center City

Researchers are evaluating physiological changes in the autonomic nervous system during opioid withdrawal and cravings in people with a history of opioid dependence. This observational trial involves 20 participants who have been dependent on prescription or non-prescription opioids. The goal is to better understand how withdrawal symptoms and cravings affect the body's physiological signals throughout a 14-day inpatient detoxification treatment. During the 14-day treatment, participants will continuously wear two devices: the EmbracePlus Smartwatch and the Corti Sensor. The EmbracePlus Smartwatch monitors heart rate, heart rate variability, skin conductance, skin temperature, movement, and blood oxygen saturation under specific conditions. The Corti Sensor, worn on the forearm, measures sweat levels of cortisol, melatonin, and inflammatory proteins. Both devices collect data continuously to capture detailed physiological changes during detoxification. Participants will be monitored daily using opioid withdrawal and craving scales, including the Short Opioid Withdrawal Scale Gossop (SOWS-Gossop), Clinical Opioid Withdrawal Scale (COWS), and the Opioid Craving Visual Analog Scale (OC-VAS). Adverse events will also be tracked each day. Researchers will analyze these measurements alongside the continuous physiological data collected by the wearable sensors to better understand opioid withdrawal symptoms and cravings over the 14-day period.