Canfield

Researchers are evaluating the effects of Ginseng and Cordyceps supplements on aerobic capacity, lactate kinetics, and nitric oxide levels in healthy adults aged 40 to 65. This randomized, double-blind, placebo-controlled trial involves 75 participants and aims to assess potential benefits related to energy, recovery, mood, and quality of life over a 30-day period. Participants are randomly assigned to one of three groups receiving either 250 mg Panax Ginseng extract, 1 gram Cordyceps Militaris extract, or a placebo with maltodextrin. The study lasts 30 days, with supplementation taken daily. There are three study visits screening, baseline Day 0, and Day 30, during which various physical and biochemical tests are performed. Participants will complete questionnaires on recovery, mood, energy, fatigue, and quality of life at baseline and the end of the study. Physical assessments include VO2 max test, time-to-exhaustion, handgrip strength, and isometric mid-thigh pull. Blood tests will measure circulating nitratesnitrites, circulatory efficiency, and lactate kinetics. Side effects and adverse events will be monitored throughout the study to ensure safety.

Researchers are investigating how an amylopectin chromium blend affects whole-body protein balance in peri- and post-menopausal women aged 40 to 65. This study aims to understand if the supplement can support positive protein balance during midlife hormonal changes and whether a concentrated dose may be effective. The study also evaluates glucose control using continuous monitoring over 24 hours. Participants will be randomly assigned to one of three groups a standard dose of the amylopectin-chromium blend, a concentrated dose, or a placebo containing amylopectin alone. Each participant will consume the assigned supplement with 20 grams of yogurt protein immediately after a short resistance exercise session. A second protein serving will be taken later with an evening meal. The study includes four in-person visits over 2 to 3 weeks, including screening, baseline assessments, exercise familiarization, and the main intervention day. Throughout the study, participants will follow a controlled diet and avoid caffeine, alcohol, and strenuous exercise before visits. Researchers will collect blood and urine samples to measure protein synthesis and breakdown, using stable isotope tracers, and will monitor glucose levels continuously. Safety and tolerability will be tracked during visits. The main outcomes are changes in protein turnover and glucose control, helping to guide nutritional strategies for muscle and metabolic health in midlife women.

Researchers are evaluating a dietary supplement called Miricell to see if it supports cellular health and healthy aging in adults aged 40 to 70. The trial aims to learn if Miricell improves autophagy, the bodys natural process for recycling damaged cells, and whether it benefits brain health, metabolic health, and visible signs of aging. The study also monitors any medical problems participants may experience while taking Miricell compared to a placebo. Participants are randomly assigned to take either one capsule of Miricell, which contains a standardized spermidine ingredient, or a placebo capsule each day for 12 weeks. Both capsules look identical to keep the study double-blind. Participants follow strict dietary guidelines to maintain consistent intake of polyamine-rich foods and other lifestyle habits to minimize variables. They take the capsules with a morning meal and follow specific fasting and diet instructions before scheduled lab visits. During the study, participants visit the research clinic four times for checkups and tests. They complete memory and thinking assessments, track daily physical activity, and provide blood samples at baseline, week 6, and week 12 to measure markers like serum Beclin-1 and ULK1 concentrations. Safety is closely monitored, with adverse events evaluated by medical staff. The total participation lasts for 12 weeks, with continuous monitoring to ensure protocol compliance and data quality.

Researchers are studying the effects of citicoline on mood in healthy adults aged 21 to 65. This randomized, double-blind, placebo-controlled trial aims to compare mood changes between those taking citicoline and those receiving a placebo, with the goal of understanding how citicoline may influence mood in people without major health issues. The study involves a 4-week treatment period during which participants will be randomly assigned to receive either oral citicoline or a matching placebo. The trial is designed to keep both participants and researchers unaware of which treatment is given, ensuring unbiased results. Participants will maintain their usual diet, physical activity, and caffeine intake throughout the study. During the trial, participants will undergo cognitive assessments and complete questionnaires to measure mood, sleep quality, and stress levels. Blood samples will be collected to analyze brain-related biomarkers. The main outcome is the Total Mood Disturbance score after 4 weeks. Safety and adherence will be monitored, and the entire study duration for each participant is approximately one month.