Kent

This research evaluates anonymous, previously collected medical data to review the outcomes of different treatment methods for chronic pain. The study is a retrospective review involving multiple centers and independent patient groups to compare results across various subgroups. The study examines clinical outcomes related to the use of spinal cord stimulation, radiofrequency (RF), and other implantable device systems from Boston Scientific and other manufacturers. Multiple cohorts will be analyzed based on the type of treatment system used. Participants' medical charts will be reviewed to measure response rates through approximately two years of follow-up. The study focuses on clinical results documented in patient records without any new treatment or intervention administered during the study.

Researchers are evaluating whether Solarplast (R) supplementation can help active adults recover better after heavy resistance exercise. The study focuses on whether Solarplast (R) reduces muscle damage and inflammation, and lessens performance decline caused by intense resistance training. The research compares Solarplast (R) to a placebo to see if it improves recovery. Participants will take either Solarplast (R) or a placebo daily for 28 days before performing heavy resistance exercise. They will visit the laboratory at least once per week to receive their supplement. After the supplementation period, participants will complete three consecutive lab visits involving heavy resistance training sessions followed by follow-up testing. During the study, participants will undergo tests measuring muscle damage by tracking creatine kinase activity within 48 hours after exercise. They will also report their exercise habits and health status through questionnaires. The study involves weekly visits during supplementation and multiple visits after exercise sessions to monitor recovery and performance changes.

Researchers are investigating the effects of endurance treadmill exercise on motor symptoms in people with early-stage Parkinson Disease who have not yet started medication. This Phase 3, multi-site, randomized, evaluator-masked study involves 370 participants aged 40 to 80 years with idiopathic Parkinson Disease. The main goal is to see if high-intensity treadmill exercise can slow the progression of Parkinson's motor symptoms over 12 months, measured by the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score. Participants are randomly assigned to one of two groups exercising on a treadmill 4 days per week for 30 minutes each session, targeting either 60-65% or 80-85% of their maximum heart rate. The study also examines secondary outcomes like brain imaging results, walking ability, daily activity, cognition, quality of life, fitness, and blood biomarkers at 12 and 18 months. The trial includes about 29 sites across the USA and Canada, involving collaborations between movement disorder specialists and exercise experts. Throughout the study, participants will undergo various assessments including motor symptom evaluations, brain scans, mobility tests, cognitive and quality of life questionnaires, and blood tests. The study will also explore the lasting effects of exercise after study support ends at 24 months. Safety and adherence will be closely monitored, and the total duration of participant involvement may extend up to two years to evaluate the durability of exercise benefits.

Researchers are evaluating the use of the Keen2 awareness bracelet, a digital behavioral tool, for adults with trichotillomania, a hair-pulling disorder. This single-arm, open-label trial aims to test the feasibility and preliminary behavioral impact of this device paired with a mobile app over an eight-week period. The study focuses on adults aged 18 and older who experience recurrent hair-pulling and seeks to assess usability, adherence, and changes in hair-pulling severity and awareness. Participants will wear the Keen2 bracelet, which uses motion sensors to detect hand movements linked to hair-pulling and delivers gentle vibration alerts. In the first four weeks, they will log contextual details like emotions, location, and activities after each detected episode. In weeks five through eight, the system will provide personalized predictive vibration alerts to encourage behavior changes using three strategies: stimulus control, competing response training, and coping techniques. During the study, participants will complete assessments of hair-pulling severity at baseline, week 4, and week 8, with a follow-up at week 12. Researchers will collect data on usability, adherence, and participant feedback regarding device helpfulness and knowledge of intervention strategies. Participants must have access to a compatible mobile device and internet to engage with the app and study activities over the eight weeks.