Quaker City

Researchers are evaluating whether antiseptic-coated sutures can reduce the risk of postoperative pancreatic fistulas in patients undergoing pancreatoduodenectomy, also known as the Whipple procedure. This trial is a randomized controlled study aiming to compare the rate of pancreatic fistulas within 90 days after surgery between patients receiving antiseptic-coated sutures and those receiving standard sutures. The study seeks to determine if antiseptic-coated sutures provide a superior outcome in preventing this complication. Participants will be randomly assigned to one of two groups: one group will have pancreatoduodenectomy surgery using antiseptic-coated sutures (Ethicon PDS Plus Antibacterial Sutures) applied at the pancreatojejunostomy layer throughout the surgery. The other group will receive the standard non-antiseptic coated sutures during their procedure. Both types of sutures are currently available and used in clinical practice at the study center. During the study, participants will be monitored for up to 90 days after surgery to assess the occurrence of pancreatic fistulas. Researchers will collect data on postoperative outcomes to compare the two suturing methods. Participants will be evaluated through clinical assessments and follow-up visits during this period to ensure safety and to measure the primary outcome of fistula rate.