Forest Grove

Researchers are evaluating the effects of oral dietary carotenoid supplements on various aspects of retinal health in healthy adults aged 18 to 75 years. The study focuses on how these supplements may influence macular pigment optical density (MPOD), which helps protect the retina by reducing waste accumulation. It also examines macular structure, including retinal thickness and blood vessel density, as well as visual functions like contrast sensitivity and photostress recovery time. Additionally, the study explores the relationship between carotenoid levels in the skin and eyes and investigates the impact on cognitive function related to working memory. Participants will receive either a carotenoid supplement or a placebo in softgel capsule form, taken once daily with a meal for three months. The study involves three visits: an initial visit for informed consent, history-taking, questionnaires on light sensitivity and diet, and non-invasive eye and cognitive tests without eye drops or dyes. Follow-up visits occur at one month and three months, during which the same measurements are repeated to assess changes over time. During the study, participants undergo various assessments including measurements of contrast sensitivity, photostress recovery, MPOD, blood pressure, eye pressure, skin carotenoid levels, retinal thickness, vascular health via optical coherence tomography, lipofuscin levels by fundus autofluorescence imaging, and cognitive working memory tests. The main outcomes measured are changes in MPOD and fundus autofluorescence brightness after three months. Safety and adherence are monitored throughout the study duration.