Bien Hoa

Gastric cancer is a serious health problem worldwide, and surgery is the main treatment option for cure. This research focuses on comparing two surgical methods for treating locally advanced gastric cancer that requires total gastrectomy. While open total gastrectomy (OTG) has been the standard, laparoscopic total gastrectomy (LTG) is being studied for its safety, feasibility, and long-term outcomes, especially since previous trials mainly addressed early-stage cancer and not advanced disease. The study is a prospective randomized controlled trial conducted in settings where many patients are diagnosed at advanced stages and aims to provide evidence on LTG's benefits and risks compared to OTG. Participants receive either laparoscopic gastrectomy or open total gastrectomy for tumors classified as stage cT2-4a without distant metastasis. The laparoscopic procedure uses a minimally invasive approach, while the open surgery follows traditional methods. The study evaluates both short- and mid-term outcomes after surgery, including survival and relapse rates. The surgical experience and technical advances have allowed LTG to become more common, but this trial aims to clarify its role for advanced cases. Participants are monitored over a three-year period to assess overall survival and relapse-free survival after surgery. Researchers will collect data on surgical safety, recovery, and cancer outcomes. Patients must meet specific health criteria and agree to participate with informed consent. This follow-up includes regular imaging and clinical evaluations to track the progress and detect any cancer recurrence or complications, providing important insight into the effectiveness of laparoscopic versus open surgery for gastric cancer.