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Researchers are evaluating two different methods for moving the entire upper teeth backward maxillary dentition distalization in patients with skeletal Class II malocclusion or maxillary protrusion. This randomized controlled trial compares the use of a Sliding Jig versus Retraction Hooks, both anchored by infrazygomatic crest IZC miniscrews. The study aims to understand differences in treatment speed, tooth movement types, anchorage stability, patient comfort, and side effects. Participants will be randomly assigned to receive either the Sliding Jig or Retraction Hooks method. Both use IZC miniscrews placed near the upper molars to help move teeth backward. Force is applied using nickel-titanium springs every 4 weeks, with treatment continuing until a target tooth movement or 6 months is reached. All patients will have fixed orthodontic appliances with stainless steel wires, and miniscrew stability will be monitored regularly. During the study, patients will have dental scans, X-rays, photos, and models taken to measure tooth movement and anchorage changes. Patient-reported pain and oral hygiene difficulties are recorded through questionnaires. Researchers will track side effects like miniscrew mobility and soft tissue irritation. The primary outcome is the rate of molar distalization measured over about 5 months. The total study duration varies by participant. Data will be analyzed for treatment effectiveness and patient experience.

This research aims to study changes in the alveolar bone and root resorption in patients with unilateral buccally displaced maxillary canines BDMCs undergoing orthodontic traction. It compares two different orthodontic techniques to understand their effects on bone and root structure. Buccally displaced canines are a challenging orthodontic problem due to limited bone and the risk of root damage and bone loss, making this study important for improving treatment methods. Participants will be randomly assigned to one of two treatment groups. One group will use a frictionless T-loop device made from titanium molybdenum alloy wire to move the canine over about three months, followed by bonding brackets on all teeth for alignment. The other group will receive braces on all teeth and a piggyback double wire technique to align teeth and apply traction to the displaced canine. Both methods involve gradual tooth movement with specific wire sizes and sequences. During the study, participants will have CBCT scans before and after treatment to measure 3-D changes in alveolar bone thickness and height, as well as root resorption. These measurements will be taken at the start and after approximately 8 months of treatment. Researchers will monitor bone and root changes on the treated side compared to the normal side. The study includes regular orthodontic assessments and aims to provide detailed information about the effects of these two orthodontic techniques over the treatment period.

This clinical trial evaluates the use of autologous platelet-rich fibrin PRF to promote bone regeneration after cystic enucleation in the jaws. The study compares the healing outcomes of PRF treatment to conventional surgical management in patients with odontogenic cysts. It aims to assess whether PRF, a material rich in growth factors, can enhance the bone healing process following surgery. Participants undergoing cystic enucleation will be randomly assigned to one of two groups. One group will receive PRF prepared from their own blood, applied directly to the bone defect during surgery. The other group will receive standard surgical treatment without PRF. Both groups will have their osseous defects managed according to their assigned procedure. Participants will be monitored through clinical and radiographic assessments to measure bone regeneration and healing rates. The primary outcome is radiographic bone regeneration six months after surgery. The study requires follow-up visits to evaluate healing progress, with participation lasting through the initial surgery and subsequent monitoring period.

Researchers are evaluating the effectiveness of two biological treatments, autologous Platelet-Rich Fibrin PRF and Gentamicin-Loaded PRF, as supportive therapies in primary palatoplasty surgery for children and adolescents with various types of cleft palate. The study aims to compare these treatments against the standard palatoplasty procedure to see if they improve tissue healing and reduce the chance of surgical complications such as wound breakdown and oronasal fistulas. Participants will be randomly assigned to one of three groups standard palatoplasty without any biological adjuncts, palatoplasty with autologous PRF, or palatoplasty with gentamicin-loaded PRF. The gentamicin-loaded PRF is studied for its potential antimicrobial properties in addition to supporting healing. Each participant will undergo their assigned surgical treatment as part of the trial. During the study, researchers will monitor wound healing and surgical outcomes at specific time points wound dehiscence rates and healing scores will be assessed at 7, 14, and 30 days after surgery, while the rate of palatal fistula formation will be evaluated at 3 months postoperatively. The trial includes pediatric and adolescent patients aged from 3 months to 18 years and will last until December 2028. Consent from parents or legal guardians is required for participation.

Researchers are evaluating two different vitamin D3 supplementation plans during early pregnancy to see how they affect the risk of preeclampsia in women with vitamin D deficiency. This study is a randomized controlled trial conducted at Al-Thawra Modern General Hospital in Sanaa, Yemen, focusing on pregnant women with confirmed vitamin D deficiency between 8 and 18 weeks of gestation. Participants will be randomly assigned to one of two groups one group will receive 50,000 IU of vitamin D3 every two weeks, and the other will receive 5,000 IU weekly. Both groups will continue supplementation until delivery alongside their standard antenatal care. The study aims to compare the impact of these dosing schedules on reducing preeclampsia risk and other maternal and neonatal outcomes. Throughout the pregnancy, women will be monitored for the development of preeclampsia and other health outcomes for both mother and baby. Researchers will assess the incidence and severity of preeclampsia, gestational diabetes, hypertension, birth weight, preterm birth, and neonatal health measures. The study will follow participants from enrollment until delivery, and maternal mortality will be tracked up to 42 days postpartum, with neonatal outcomes observed until 28 days after birth.