Actively Recruiting
Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
Led by Shirley Ryan AbilityLab · Updated on 2026-03-17
115
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
Sponsors
S
Shirley Ryan AbilityLab
Lead Sponsor
U
University of California, Los Angeles
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals with hemiplegia due to stroke.
CONDITIONS
Official Title
Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able and willing to give written consent and comply with study procedures
- At least 6 months post-stroke
- Hemiplegia due to a single stroke
- Functional Ambulation Category of 2 or greater, needing continuous or intermittent support to help with balance and coordination
- Not currently receiving regular physical therapy services
- Physician approval to participate
You will not qualify if you...
- Ataxia
- History of multiple strokes
- Botox injection in lower extremity within the last 4 months
- Modified Ashworth score of 3 or greater in lower extremity
- Pregnant or nursing
- Using a powered implanted cardiac device such as pacemaker, defibrillator, or LVAD, or anti-spasticity implantable pumps
- Active pressure sores
- Unhealed bone fractures
- Peripheral neuropathies
- Painful musculoskeletal dysfunction due to active injuries or infections
- Severe contractures in the lower extremities
- Medical illness limiting ability to walk
- Active urinary tract infection
- Clinically significant depression, psychiatric disorders, or ongoing drug abuse
- Active cancer or cancer in remission less than 5 years
- Orthopedic dysfunction, injury, or surgery impacting lower extremity use
- Traumatic brain injury or other neurological conditions affecting the study
- Medications affecting motor system excitability (e.g., amphetamines, lorazepam)
- Implanted cardiac pacemaker
- Metal implants in head or face
- Unexplained recurring headaches
- Seizures unrelated to stroke or epilepsy
- Skull abnormalities or fractures
- Concussion within last 6 months
- Unstable cardiorespiratory or metabolic diseases such as cardiac arrhythmia, uncontrolled hypertension, uncontrolled diabetes, or chronic emphysema
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
K
Kelly McKenzie, DPT
CONTACT
S
Sara Prokup, DPT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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