Actively Recruiting
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells.
Led by IRCCS SYNLAB SDN · Updated on 2024-04-03
20
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
Sponsors
I
IRCCS SYNLAB SDN
Lead Sponsor
F
Fondazione Santobono Pausilipon
Collaborating Sponsor
AI-Summary
What this Trial Is About
Long non-coding RNAs (lncRNAs) are a class of biomarkers of crescent interest in the hematologic and oncologic field. They do not encode proteins and can alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin structure. Recent data identified recurrent somatic alterations in genes involved in DNA methylation and post-translational histone modifications in T-ALL, suggesting that epigenetic homeostasis is critically required in restraining tumor development in the T-cell lineage. Further, recent studies showed that the expression levels of specific lncRNAs correlate with the prognosis of patients with Acute Lymphoblastic Leukemia of T-cells (T-ALL). The objectives of this research project are to identify T-ALL-specific lncRNAs to be used as new diagnostic and prognostic biomarkers of disease and to explore their role on chromatin reorganization and transcriptional regulation that may lead to the onset and progression of T-ALL.
CONDITIONS
Official Title
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a diagnosis of T-ALL aged 1 to 18 years, of both sexes
- Presence of leukemic cells in peripheral blood of recruited patients
You will not qualify if you...
- Patients who refuse to participate in the study
- Patients not falling in the age group of 1 to 18 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Irccs Synlab Sdn
Naples, Italy, 80143
Actively Recruiting
Research Team
L
Laura Pierri, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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