Actively Recruiting
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
Led by Nantes University Hospital · Updated on 2025-01-17
300
Participants Needed
5
Research Sites
225 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between respiratory tract infections (i.e. pneumonia) and the progression of cardiovascular disease. More specifically, the project aims to quantify the burden of cardiovascular disease after pneumonia and assess patients\' acceptability of long-term health alterations, as well as to define pneumonia endotypes with distinct pathobiological mechanisms associated with exacerbation of cardiovascular disease.
CONDITIONS
Official Title
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 40 years or older
- Hospitalized for acute coronary syndrome less than 7 days ago (Group A)
- Undergoing coronary artery bypass surgery and hospitalized in intensive care unit for more than 12 hours (Group B)
- Familial high cholesterol or triglycerides with no personal cardiovascular disease and recent negative cardiac exercise test within 12 months (Group C)
- At least one cardiovascular disease risk factor and recovered from mechanically ventilated hospital-acquired pneumonia during current hospitalization (Group D)
- Provided informed consent
- Covered by a health insurance plan
You will not qualify if you...
- Older than 80 years
- Immunosuppression before current hospital stay (including low lymphocyte count, blood cancers, aplasia, recent chemotherapy/radiotherapy, or anti-graft rejection drugs)
- Pregnant or breastfeeding women
- Adults under guardianship or trusteeship
- Low chance of survival at 28 days
- History of community-acquired or hospital-acquired pneumonia within the last year (Groups A, B, C)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Angers University Hospital
Angers, France
Not Yet Recruiting
2
Nantes University Hospital
Nantes, France
Actively Recruiting
3
Rennes University Hospital
Rennes, France
Not Yet Recruiting
4
Rouen University Hospital
Rouen, France
Not Yet Recruiting
5
Toulouse University Hospital
Toulouse, France
Not Yet Recruiting
Research Team
A
Antoine ROQUILLY
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
4
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