Actively Recruiting

Phase Not Applicable
Age: 50Years +
All Genders
Healthy Volunteers
NCT05373043

Long-term COVID and Rehabilitation

Led by VA Office of Research and Development · Updated on 2025-09-18

300

Participants Needed

1

Research Sites

313 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.

CONDITIONS

Official Title

Long-term COVID and Rehabilitation

Who Can Participate

Age: 50Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • 50 years of age or greater
  • Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis
  • Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis
  • Ability to sign informed consent
Not Eligible

You will not qualify if you...

  • Body mass index (BMI) greater than 45 kg/m2
  • Unstable or severe coronary artery disease within the last 6 months
  • Severe peripheral artery disease with Ankle Brachial Index less than 0.40
  • Cerebrovascular disease such as stroke in the last 12 months
  • Severe chronic obstructive pulmonary disease (Stage III)
  • Uncontrolled hypertension above 160/100 mmHg
  • Chronic kidney disease requiring dialysis or severe renal insufficiency (creatinine clearance less than 30)
  • Alzheimer's disease or dementia
  • Orthopedic limitations preventing exercise
  • Current smokers or those who stopped smoking within the last 10 years
  • Already taking Mitoquinone (Mito-Q) or unwilling to stop dietary supplements for participation
  • Any other condition or event deemed exclusionary by the principal investigators or a physician

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

VA Salt Lake City Health Care System, Salt Lake City, UT

Salt Lake City, Utah, United States, 84148-0001

Actively Recruiting

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Research Team

J

Joel D Trinity, PhD

CONTACT

R

Russell S Richardson, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Long-term COVID and Rehabilitation | DecenTrialz