Evaluating the Long-term Health Consequences of COVID-19 and Rehabilitation Therapies to Speed Convalescence

What this Trial Is About

This research aims to evaluate the long-term effects of COVID-19 on vascular endothelial function and overall health in older Veterans, including those experiencing long-COVID symptoms such as fatigue, weakness, and cognitive difficulties. The study focuses on understanding how oxidative stress and inflammation caused by aging and COVID-19 impact vascular health and recovery, with the goal of improving rehabilitation strategies to reduce health risks and enhance recovery outcomes. Participants will be assigned to one of two groups: exercise-based rehabilitation combined with a mitochondria-targeted antioxidant supplement called Mito-Q, or exercise-based rehabilitation with a placebo. These interventions are designed to improve vascular function by reducing oxidative stress and inflammation. The study includes a 4-year observation period with tests conducted twice annually to assess vascular health and the effectiveness of the rehabilitation approaches. Throughout the study, participants will undergo assessments of vascular endothelial function using several tests, including flow-mediated dilation, passive leg movement, and breath-hold acceleration index, at baseline and multiple follow-up times up to 4 years. Researchers will also monitor neurocognitive and pulmonary function, along with overall health risks and outcomes. The study involves regular evaluations to track progress and safety, aiming to provide clear recommendations for rehabilitation in older Veterans recovering from COVID-19 and those without COVID-19 history.

Long-term COVID and Rehabilitation