Actively Recruiting
Long Term Effect of Brain Stimulation in PPA
Led by Hospital San Carlos, Madrid · Updated on 2026-04-23
80
Participants Needed
1
Research Sites
167 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the effect of non-invasive brain stimulation techniques in the progression of primary progressive aphasia for 6 months. We will compare three modalities of brain stimulation (TMS, tDCS, TMS+tDCS) against sham stimulation. All patients will receive also language therapy.
CONDITIONS
Official Title
Long Term Effect of Brain Stimulation in PPA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Primary Progressive Aphasia (PPA) based on current consensus criteria
- Diagnosis of one of the three PPA variants: non-fluent, semantic, or logopenic, supported by neuroimaging
- Clinical Dementia Rating scale score of 1 or less
- Language impairment is the main neurological deficit for the patient
You will not qualify if you...
- Diagnosis of a condition other than PPA that causes language impairment
- History of epilepsy or epileptiform activity on EEG
- Contraindications to TMS or tDCS such as ferromagnetic material, pregnancy, or breastfeeding
- Terminal illness or active cancer
- Alcohol or substance abuse within the past year
- Major psychiatric disorders including schizophrenia, bipolar disorder, obsessive-compulsive disorder, or personality disorders
- Complete inability to communicate or poor language command preventing study participation
- Severity of PPA that prevents participation in interventions or assessments
- Participation in another clinical trial within the past 4 months
- Chronic use of medications affecting study outcomes unless stable for at least 3 months
- Specific allowed medications include antiepileptic drugs, diazepam and derivatives, donepezil, galantamine, rivastigmine, memantine, SSRIs; others that may lower seizure threshold allowed if stable for 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Clinico San Carlos
Madrid, Spain
Actively Recruiting
Research Team
J
Jordi Matias-Guiu, PhD MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here