Actively Recruiting
Long-term Effectiveness of the Live Attenuated Herpes Zoster Vaccine in Adults 40 Years or Older: A Multicenter Retrospective Cohort Study Based on Phase III Trial
Led by Jiangsu Province Centers for Disease Control and Prevention · Updated on 2026-05-13
24740
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Jiangsu Province Centers for Disease Control and Prevention
Lead Sponsor
Z
Zhejiang Provincial Center for Disease Control and Prevention (Zhejiang Provincial Academy of Preventive Medicine)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the long-term effectiveness of a live attenuated herpes zoster vaccine in adults aged 40 years or older. This multicenter retrospective cohort study focuses on participants from a previous Phase III Clinical Trial conducted in 2020-2021, comparing those who originally received the vaccine with those who received a placebo. The study aims to assess the occurrence of herpes zoster over a period of up to six years after vaccination, including the impact of catch-up vaccination given after the vaccine’s marketing authorization in China.
CONDITIONS
Brief Title
Long-term Effectiveness of the Live Attenuated Herpes Zoster Vaccine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals included in the E-mFAS from the Phase III Clinical Trial (NCT04334577) of the live attenuated herpes zoster vaccine conducted during 2020-2021
- Individuals able to complete the study and provide verbal informed consent
- Adults aged 40 years or older
You will not qualify if you...
- Individuals who developed herpes zoster during the original Phase III Clinical Trial follow-up period
- Individuals known to have died before the retrospective study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - From July 2021 to the survey date in 2026
Participants are observed for the incidence of herpes zoster following their original assignment to vaccine or placebo groups, including a catch-up vaccination period for some placebo participants.
Trial Site Locations
Total: 1 location
1
Jiangsu Provincial Center for Diseases Control and Prevention (Jiangsu Provincial Academy of Preventive Medicine)
Nanjing, Jiangsu, China
Actively Recruiting
Research Team
P
Pengfei Jin
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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