Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
NCT06251752

Long Term Evaluation of Clinical and Radiologic Results on Femoro-patellar Joint After High Tibial Osteotomy

Led by Istituto Ortopedico Rizzoli · Updated on 2026-02-23

50

Participants Needed

1

Research Sites

318 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Osteotomies are among the oldest orthopedic treatments, in use for over 2000 years and still commonly employed. The basic principle involves making a bone cut to allow the realignment of the limb segment affected by deformity. Today, new knowledge and technologies, understanding of bone healing mechanisms, and the introduction of new fixation methods have made osteotomies one of the preferred treatments for early knee arthritis. They serve as an alternative to joint prosthesis implantation in young patients with medium to high functional demand. Medial knee osteoarthritis is a pathology increasingly prevalent in today's population. The resulting varus deformity leads to a shift in the load axis on the medial tibial plateau. Osteotomy in this context becomes a therapeutic tool capable of restoring the correct mechanical axis of the lower limb and delaying or avoiding the progression of arthritis, thus avoiding the need for joint replacement. The two most commonly used techniques are the Closing Wedge Lateral High Tibial Osteotomy (LCW-HTO) and the Opening Wedge Medial High Tibial Osteotomy (MOW-HTO), which are high tibial osteotomies in closure with a wedge removal and in opening with a wedge insertion, respectively. The medium to long-term effects of this procedure, in terms of survival and modification of the tibial slope, have been extensively studied, as evidenced by the extensive literature on the subject. However, the effect of this intervention, in its two variants, on the progression of femoro-patellar arthritis and the height of the patella remains poorly investigated to date.

CONDITIONS

Official Title

Long Term Evaluation of Clinical and Radiologic Results on Femoro-patellar Joint After High Tibial Osteotomy

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of medial unicompartmental knee osteoarthritis (Outerbridge III-IV)
  • Follow-up longer than 60 months
  • Complete clinical and radiographic documentation available
  • Previous valgus osteotomy procedure (MOW-HTO or LCW-HTO)
  • Age less than 65 years
Not Eligible

You will not qualify if you...

  • Previous injuries affecting the involved lower limb
  • Prior traumatic, septic, or rheumatoid arthritis
  • Previous alterations of the patellofemoral joint
  • Knee ligament injuries
  • Confirmed neuromuscular disorders or psychomotor disturbances
  • Congenital generalized hypermobility syndrome
  • Severe diseases in other organs or systems limiting daily activities
  • Refusal to participate in the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

IRCCS Istituto Ortopedico Rizzoli

Bologna, Italy, 40136

Actively Recruiting

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Research Team

G

Giulio Maria Marcheggiani Muccioli, MD PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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