Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06747949

A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

Led by Amgen · Updated on 2026-04-28

844

Participants Needed

174

Research Sites

250 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The primary objective of this study is to evaluate the long-term safety and tolerability of dazodalibep.

CONDITIONS

Official Title

A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participant has provided informed consent before starting any study activities.
  • Must have completed a phase 3 dazodalibep or placebo study for Sjögren's Syndrome through Week 48.
  • Must be able to receive the first dose of this extension study within 28 days after Week 48 of the prior phase 3 study.
Not Eligible

You will not qualify if you...

  • Has a clinically significant active infection at Day 1 requiring antibiotics or antiviral medication.
  • Plans to participate in another clinical study with investigational products or procedures during this study.
  • Has any health condition or change reported during prior phase 3 studies that would interfere with safety evaluation or increase risk.
  • Plans surgeries or hospitalizations that would interfere with safety evaluation.
  • Plans to receive live (attenuated) vaccines during this study.
  • Female participants of childbearing potential unwilling to use required contraception during and 12 weeks after treatment.
  • Pregnant, lactating, or planning pregnancy during the study.
  • Known sensitivity to any study products or components.
  • Unlikely to complete all study visits or comply with study procedures.
  • Has any other significant medical disorder posing safety risks or interfering with study evaluation as judged by investigators.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 174 locations

1

Arizona Arthritis & Rheumatology Associates - Avondale

Avondale, Arizona, United States, 85392

Actively Recruiting

2

Arizona Arthritis and Rheumatology Associates - Flagstaff - 399 S Malpais Ln

Flagstaff, Arizona, United States, 86001-6269

Actively Recruiting

3

Arizona Arthritis and Rheumatology Associates - Gilbert - 3645 S Rome St

Gilbert, Arizona, United States, 85297-7336

Actively Recruiting

4

Arizona Arthritis and Rheumatology Associates - Glendale - 5681 W Beverly Ln

Glendale, Arizona, United States, 85306-9800

Actively Recruiting

5

Arizona Arthritis and Rheumatology Associates - Tucson - 2001 W Orange Grove Rd

Tucson, Arizona, United States, 85704-1139

Actively Recruiting

6

Samy Metyas MD Inc

Covina, California, United States, 91723

Actively Recruiting

7

UCSD Altman Clinical and Translational Research Institute Building

La Jolla, California, United States, 92037-1337

Actively Recruiting

8

Tekton Research, LLC - 2121 E Harmony Rd - PPDS

Fort Collins, Colorado, United States, 80528-3400

Actively Recruiting

9

Bradenton Research Center Inc

Bradenton, Florida, United States, 34205-1704

Actively Recruiting

10

Clinical Research of West Florida Inc - Clearwater

Clearwater, Florida, United States, 33765-2616

Actively Recruiting

11

BayCare Medical Group Primary Care and Rheumatology - Tampa

Tampa, Florida, United States, 33614-7101

Actively Recruiting

12

Tufts University School of Dental Medicine

Boston, Massachusetts, United States, 02111-1527

Actively Recruiting

13

Shores Rheumatology

Saint Clair Shores, Michigan, United States, 48081-1274

Actively Recruiting

14

Kansas City Physician Partners-8350 N Saint Clair Ave

Kansas City, Missouri, United States, 64151

Actively Recruiting

15

Arthritis, Rheumatic & Bone Disease Associates - Voorhees

Voorhees Township, New Jersey, United States, 08043-4501

Actively Recruiting

16

Arthritis and Osteoporosis Consultants of The Carolinas - Charlotte - 1918 Randolph Rd

Charlotte, North Carolina, United States, 28207-1100

Actively Recruiting

17

Duke Early Phase Clinical Research Unit - PPDS

Durham, North Carolina, United States, 27710-0001

Actively Recruiting

18

Onsite Clinical Solutions, LLC - Salisbury

Salisbury, North Carolina, United States, 28144

Actively Recruiting

19

Arthritis & Osteoporosis Center of Southwest Ohio - Miamisburg

Miamisburg, Ohio, United States, 45342-3585

Actively Recruiting

20

University of Toledo Medical Center

Toledo, Ohio, United States, 43614-2595

Actively Recruiting

21

STAT Research-600 Aviator Ct

Vandalia, Ohio, United States, 45377-9474

Actively Recruiting

22

Murfreesboro Medical Clinic Westlawn

Murfreesboro, Tennessee, United States, 37128

Actively Recruiting

23

Accurate Clinical Management-Baytown

Baytown, Texas, United States, 77521-2279

Actively Recruiting

24

Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, United States, 76034-5913

Actively Recruiting

25

R & H Clinical Research-777 S Fry Rd

Katy, Texas, United States, 77450-2297

Actively Recruiting

26

Houston Rheumatology & Arthritis Specialists - PLLC - PPDS

Katy, Texas, United States, 77494-1341

Actively Recruiting

27

Biopharma Informatic - Ridge Road - PPDS

McAllen, Texas, United States, 78503-1527

Actively Recruiting

28

Advanced Rheumatology of Houston

The Woodlands, Texas, United States, 77382-2935

Actively Recruiting

29

DM Clinical Research - Migraine and COPD - PPDS

Tomball, Texas, United States, 77375

Actively Recruiting

30

Western Washington Medical Group, Bothell - Rheumatology

Bothell, Washington, United States, 98021

Actively Recruiting

31

Rheumatology and Pulmonary Clinic

Beckley, West Virginia, United States, 25801-2805

Actively Recruiting

32

Consultorios Médicos Dr. Doreski - Fundacion Respirar - PPDS

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ABP

Actively Recruiting

33

Instituto CER S.A.

Quilmes, Buenos Aires, Argentina, B1878DVB

Actively Recruiting

34

Instituto de Investigaciones Clinicas Quilmes SRL

Quilmes, Buenos Aires, Argentina, B1878GEG

Actively Recruiting

35

MR Medicina Reumatologica

San Fernando, Buenos Aires, Argentina, B1646GHP

Actively Recruiting

36

DOM Centro de Reumatología

Buenos Aires, Ciudad Autónoma de BuenosAires, Argentina, C1111

Actively Recruiting

37

Centro de Investigaciones Reumatológicas

San Miguel de Tucumán, Tucumán Province, Argentina, T4000AXL

Actively Recruiting

38

Centro Medico Privado de Reumatologia - PPDS

San Miguel de Tucumán, Tucumán Province, Argentina, T4000AXL

Actively Recruiting

39

Clínica Mayo de U.M.C.B. S.R.L

San Miguel de Tucumán, Tucumán Province, Argentina, T4000IHE

Actively Recruiting

40

Aprillus Asistencia e Investigacion - Terrada 89

Buenos Aires, Argentina, 1406

Actively Recruiting

41

Hospital General de Agudos Dr. José María Ramos Mejia

Buenos Aires, Argentina, C1121ADC

Actively Recruiting

42

Sanatorio Agote - Swiss Medical Group - PPDS

Buenos Aires, Argentina, C1425EOE

Actively Recruiting

43

Centro Medico Arsema

Buenos Aires, Argentina, C1427CCL

Actively Recruiting

44

Sanatorio Allende S.A.-Hipolito Yrigoyen 384

Córdoba, Argentina, X5000JHQ

Actively Recruiting

45

Framingham Centro Médico

La Plata, Argentina, B1902COS

Actively Recruiting

46

Centro Polivalente de Asistencia e Investigación Clínica - CER San Juan

San Juan, Argentina, J5402DIL

Actively Recruiting

47

The Queen Elizabeth Hospital

Woodville South, South Australia, Australia, 5011

Actively Recruiting

48

UZ Gent

Ghent, Belgium, 9000

Actively Recruiting

49

SER - Serviços Especializados em Reumatologia da Bahia S/S - ME

Salvador, Estado de Bahia, Brazil, 40150-150

Actively Recruiting

50

Centro de Estudos em Terapias Inovadoras

Curitiba, Paraná, Brazil, 80030-110

Actively Recruiting

51

LMK Servicos Medicos SS

Porto Alegre, Rio Grande do Sul, Brazil, 90480-000

Actively Recruiting

52

Clinique de Rhumatologie Du Centre Du Quebec

Trois-Rivières, Quebec, Canada, G8Z 1Y2

Actively Recruiting

53

Centro de Investigacion de Enfermedades Respiratorias e inmunologicas

Viña del Mar, Valparaiso, Chile, 2520000

Actively Recruiting

54

Enroll SpA - Dr. Manuel Barros Borgono - PPDS

Providencia, Chile, 7500000

Actively Recruiting

55

BIOCINETIC Ltda

Santiago, Chile, 8350595

Actively Recruiting

56

Centro de especialidades médicas Vanguardia

Temuco, Chile, 4810345

Actively Recruiting

57

Clinical Research Chile SpA - PPDS

Valdivia, Chile, 5110683

Actively Recruiting

58

Polyclinic Bonifarm

Zagreb, City of Zagreb, Croatia, 10000

Actively Recruiting

59

University Hospital of Split

Split, Croatia, 21000

Actively Recruiting

60

CHU de Bordeaux - Hôpital Saint-André

Bordeaux, France, 33000

Actively Recruiting

61

CHU de Brest - Hôpital La Cavale Blanche

Brest, France, 29200

Actively Recruiting

62

GHRMSA - Hôpital Emile Muller

Mulhouse, France, 68100

Actively Recruiting

63

AP-HP - Hôpital Saint Antoine

Paris, France, 75012

Actively Recruiting

64

Hôpitaux Universitaires de Strasbourg

Strasbourg, France, 67091

Actively Recruiting

65

University Clinic Heidelberg

Heidelberg, Baden-Wurttemberg, Germany, 69120

Actively Recruiting

66

Rheumazentrum Prof. Dr. med. Gunther Neeck-Standort Bad Doberan

Bad Doberan, Mecklenburg-Vorpommern, Germany, 18209

Actively Recruiting

67

Rheumazentrum Greifswald

Greifswald Hansestadt, Mecklenburg-Vorpommern, Germany, 17493

Actively Recruiting

68

MVZ Rheuma

Hamburg, Germany, 20095

Actively Recruiting

69

Naval Hospital of Athens

Athens, Attica, Greece, 115 21

Actively Recruiting

70

Laiko General Hospital of Athens

Athens, Attica, Greece, 115 27

Actively Recruiting

71

University General Hospital of Larissa

Larissa, Larisa, Greece, 411 10

Actively Recruiting

72

Euromedica Kianous Stavros

Thessaloniki, Greece, 546 36

Actively Recruiting

73

Bekes Varmegyei Kozponti Korhaz

Gyula, Bekes County, Hungary, 5700

Actively Recruiting

74

Vasarhelyi Sarkanyfu Kft.

Hódmezovásárhely, Csongrád megye, Hungary, 6800

Actively Recruiting

75

Debreceni Egyetem Klinikai Kozpont Nagyerdei Campus

Debrecen, Hajdú-Bihar, Hungary, 4032

Actively Recruiting

76

Del-pesti Centrumkorhaz- Orszagos Hematologiai és Infektologiai Intezet - Albert Flórián út 5-7

Budapest, Hungary, 1097

Actively Recruiting

77

Meir Medical Center

Kafr Saba, Central District, Israel, 4428164

Actively Recruiting

78

The Chaim Sheba Medical Center - PPDS

Ramat Gan, Tel Aviv, Israel, 5262100

Actively Recruiting

79

Azienda Sanitaria Universitaria Friuli Centrale - PO Universitario Santa Maria della Misericordia

Udine, Friuli Venezia Giulia, Italy, 33100

Actively Recruiting

80

Fondazione Policlinico Universitario A Gemelli - Rome - PPDS

Rome, Lazio, Italy, 00168

Actively Recruiting

81

Fondazione Policlinico Universitario Campus Bio-Medico

Rome, Lazio, Italy, 128

Actively Recruiting

82

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, Italy, 20122

Actively Recruiting

83

A.O.U. Città della Salute e della Scienza di Torino

Turin, Piedmont, Italy, 10126

Actively Recruiting

84

Azienda Ospedaliera Universitaria Integrata Di Verona

Verona, Veneto, Italy, 37126

Actively Recruiting

85

Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara

Pisa, Italy, 56126

Actively Recruiting

86

AUSL di Reggio Emilia - IRCCS - Arcispedale Santa Maria Nuova

Reggio Emilia, Italy, 42123

Actively Recruiting

87

Chubu Rosai Hospital

Nagoya-shi, Akita, Japan, 455-0018

Actively Recruiting

88

Japan Community Health Care Organization (JCHO) Chukyo Hospital

Nagoya-shi, Akita, Japan, 457-0866

Actively Recruiting

89

Daido Clinic

Nagoya, Akita, Japan, 457-8511

Actively Recruiting

90

Sapporo Medical University Hospital

Sapporo, Hokkaidô, Japan, 060-8543

Actively Recruiting

91

Hokkaido University Hospital

Sapporo, Hokkaidô, Japan, 060-8648

Actively Recruiting

92

Hospital of the University of Occupational and Environmental Health, Japan

Kita Kyushu-shi, Hukuoka, Japan, 807-8556

Actively Recruiting

93

University of Tsukuba Hospital

Tsukuba, Ibaraki, Japan, 305-8576

Actively Recruiting

94

Kanazawa Medical University Hospital

Kahoku, Ishikawa-ken, Japan, 920-0293

Actively Recruiting

95

Kanazawa University Hospital

Kanazawa, Ishikawa-ken, Japan, 920-8641

Actively Recruiting

96

National Hospital Organization Yokohama Medical Center

Yokohama, Kanagawa, Japan, 245-8575

Actively Recruiting

97

University Hospital, Kyoto Prefectural University of Medicine

Kyoto, Kyôto, Japan, 602-8566

Actively Recruiting

98

Kyoto University Hospital

Kyoto, Kyôto, Japan, 606-8507

Actively Recruiting

99

Nagasaki University Hospital

Nagasaki, Nagasaki, Japan, 852-8501

Actively Recruiting

100

Sasebo Chuo Hospital

Sasebo-Shi, Nagasaki, Japan, 857-1165

Actively Recruiting

101

Kurashiki Medical Clinic

Kurashiki-Shi, Okayama-ken, Japan, 710-0824

Actively Recruiting

102

Saitama Medical University Hospital

Iruma-Gun Moroyama-Machi, Saitama, Japan, 350-0451

Actively Recruiting

103

Hamamatsu University Hospital

Hamamatsu, Shizuoka, Japan, 431-3192

Actively Recruiting

104

St. Luke's International Hospital

Chuo-Ku, Tokyo, Japan, 104-0044

Actively Recruiting

105

Nihon University Itabashi Hospital

Itabashi-Ku, Tokyo, Japan, 173-0032

Actively Recruiting

106

Tokyo Medical Center

Meguro-Ku, Tokyo, Japan, 152-0021

Actively Recruiting

107

Keio University Hospital

Shinjuku-Ku, Tokyo, Japan, 160-8582

Actively Recruiting

108

Mediadvance Clinical S.A.P.I. de C.V.

Parques de San Felipe, Chihuahua, Mexico, 31203

Actively Recruiting

109

Centro de Investigación en Artritis y Osteoporosis - PPDS

Mexicali, Estado de Baja California, Mexico, 21200

Actively Recruiting

110

Centro de Estudios de Investigacion Basica Y Clinica SC

Guadalajara, Jalisco, Mexico, 44690

Actively Recruiting

111

Centro de Investigación y Tratamiento Reumatológico S.C

Mexico City, Mexico City, Mexico, 11850

Actively Recruiting

112

Cryptex Investigación Clínica, S.A. de C.V.

Mexico City, Mexico City, Mexico, 6100

Actively Recruiting

113

Clinstile, S.A. de C.V.

Mexico City, Mexico, 6700

Actively Recruiting

114

Unidad de Atención Medica e Investigación en Salud

Mérida, Mexico, 97000

Actively Recruiting

115

Consultorio de Reumatologia

México, Mexico, 7760

Actively Recruiting

116

Optimal Clinical Trials Ltd - PPDS

Auckland, North Island, New Zealand, 1003

Actively Recruiting

117

Health New Zealand - Te Whatu Ora - Waikato (Waikato Hospital)

Hamilton, New Zealand, 3240

Actively Recruiting

118

Aotearoa Clinical Trials Trust - Middlemore Hospital - PPDS

Papatoetoe, New Zealand, 2025

Actively Recruiting

119

Clinica San Antonio S.A.C

Trujillo, La Libertad, Peru, 13008

Actively Recruiting

120

Medicentro Biociencias Peru S.R.L.

Pueblo Libre, Lima region, Peru, 1508

Actively Recruiting

121

Hospital Militar Central Luis Arias Schereiber

Jesus Maria, Peru, 15001

Actively Recruiting

122

Instituto de Ginecologia y Reproduccion - PPDS

Santiago de Surco, Peru, 33

Actively Recruiting

123

Pratia Poznan - PPDS

Poznan, Greater Poland Voivodeship, Poland, 60-192

Actively Recruiting

124

Med-Polonia Sp. z o.o.

Poznan, Greater Poland Voivodeship, Poland, 60-693

Actively Recruiting

125

Malopolskie Centrum Kliniczne

Krakow, Lesser Poland Voivodeship, Poland, 30-149

Actively Recruiting

126

Centrum Medyczne Oporow

Wroclaw, Lower Silesian Voivodeship, Poland, 52-416

Actively Recruiting

127

ETG Lublin - PPDS

Lublin, Lublin Voivodeship, Poland, 20-412

Actively Recruiting

128

Zespol Poradni Specjalistycznych REUMED- Wallenroda 2F/4

Lublin, Lublin Voivodeship, Poland, 20-607

Actively Recruiting

129

MICS Centrum Medyczne Warszawa, Wronia - MICS

Warsaw, Masovian Voivodeship, Poland, 00-874

Actively Recruiting

130

MTZ Clinical Research Powered by PRATIA - PPDS

Warsaw, Masovian Voivodeship, Poland, 02-172

Actively Recruiting

131

Centrum Medyczne Reuma Park

Warsaw, Masovian Voivodeship, Poland, 02-665

Actively Recruiting

132

WIM-PIB, Centralny Szpital Kliniczny MON

Warsaw, Masovian Voivodeship, Poland, 04-141

Actively Recruiting

133

Centrum Medyczne K2J2 - Wołomin

Wołomin, Masovian Voivodeship, Poland, 05-200

Actively Recruiting

134

Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Sp. Z o.o.

Malbork, Pomeranian Voivodeship, Poland, 82-200

Actively Recruiting

135

MICS Centrum Medyczne Bydgoszcz

Bydgoszcz, Poland, 85-065

Actively Recruiting

136

Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy

Bydgoszcz, Poland, 85-168

Actively Recruiting

137

Centrum Medyczne Pratia Katowice - PPDS

Katowice, Poland, 40-081

Actively Recruiting

138

Centrum Medyczne Plejady Magdalena Celinska - Lowenhoff, Michal Zolnowski Spolka komandytowa

Krakow, Poland, 30-363

Actively Recruiting

139

Centrum Medyczne PROMED- Olszanska 5G

Krakow, Poland, 31-513

Actively Recruiting

140

FutureMeds - Lodz - PPDS

Lodz, Poland, 91-363

Actively Recruiting

141

Twoja Przychodnia PCM

Poznan, Poland, 60-324

Actively Recruiting

142

Prywatna Praktyka Lekarska Pawel Hrycaj

Poznan, Poland, 61-397

Actively Recruiting

143

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Dr hab. Med. Eleonory Reicher

Warsaw, Poland, 02-637

Actively Recruiting

144

ETG Warszawa - PPDS

Warsaw, Poland, 02-677

Actively Recruiting

145

FutureMeds - Targowek - PPDS

Warsaw, Poland, 03-291

Actively Recruiting

146

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu - Borowska 213

Wroclaw, Poland, 50-556

Actively Recruiting

147

Pracownia Badan Klinicznych Salus - ul. Ołtaszyńska 92c/3

Wroclaw, Poland, 53-034

Actively Recruiting

148

FutureMeds - Wroclaw - PPDS

Wroclaw, Poland, 53-673

Actively Recruiting

149

ULS de Lisboa Ocidental, EPE - Hospital Egas Moniz

Lisbon, Lisbon District, Portugal, 1349-019

Actively Recruiting

150

ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS

Lisbon, Lisbon District, Portugal, 1649-035

Actively Recruiting

151

Hospital Conde de Bertiandos - Unidade Local de saúde do Alto Minho, EPE - Ponte de Lima

Ponte de Lima, Portugal, 4990-150

Actively Recruiting

152

ULS de Gaia/Espinho, EPE - Unidade I

Vila Nova de Gaia, Portugal, 4434-502

Actively Recruiting

153

Military Medical Academy

Belgrade, Belgrade, Serbia, 11000

Actively Recruiting

154

Institute of Rheumatology - PPDS

Belgrade, Serbia, 11000

Actively Recruiting

155

Klinika za Alergologiju i Imunologiju

Belgrade, Serbia, 112108

Actively Recruiting

156

University Clinical Center Kragujevac

Kragujevac, Serbia, 34000

Actively Recruiting

157

Clinical Centre of Vojvodina

Novi Sad, Serbia, 21000

Actively Recruiting

158

Special Hospital For Rheumatic Diseases Novi Sad

Novi Sad, Serbia, 21000

Actively Recruiting

159

University Clinical Centre Maribor

Maribor, Slovenia, 2000

Actively Recruiting

160

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, Seoul Teugbyeolsi, South Korea, 6591

Actively Recruiting

161

Fundacio Hospital de l'Esperit Sant

Santa Coloma de Gramenet, Barcelona, Spain, 08923

Actively Recruiting

162

C.H. Regional Reina Sofia - PPDS

Córdoba, Córdoba, Spain, 14004

Actively Recruiting

163

Hospital Universitario de Basurto

Bilbao, Vizcaya, Spain, 48013

Actively Recruiting

164

Hospital Universitario Infanta Leonor

Madrid, Spain, 28031

Actively Recruiting

165

Hospital Universitario 12 de Octubre

Madrid, Spain, 28041

Actively Recruiting

166

Hospital Quironsalud Infanta Luisa

Seville, Spain, 41010

Actively Recruiting

167

Hospital Universitario de Valme

Seville, Spain, 41014

Actively Recruiting

168

Kaohsiung Medical University - Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan, 80756

Actively Recruiting

169

Taichung Veterans General Hospital

Taichung, Taiwan, 40705

Actively Recruiting

170

Taipei Medical University Hospital - PPDS

Taipei, Taiwan, 11031

Actively Recruiting

171

Chang Gung Memorial Hospital, Linkou

Taoyuan, Taiwan, 33305

Actively Recruiting

172

Queen Alexandra Hospital

Portsmouth, Hampshire, United Kingdom, PO6 3LY

Actively Recruiting

173

Chapel Allerton Hospital - PPDS

Leeds, United Kingdom, LS7 4SA

Actively Recruiting

174

Mile End Hospital - PPDS

London, United Kingdom, E1 4DG

Actively Recruiting

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Research Team

A

Amgen Call Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) | DecenTrialz