Actively Recruiting

Phase 2
Age: 60Years +
All Genders
NCT06635148

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Led by Janssen Research & Development, LLC · Updated on 2026-05-08

274

Participants Needed

104

Research Sites

303 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to assess the long-term safety and tolerability after an intravitreal injection (a shot of medicine into the eye) of JNJ-81201887 administered in parent clinical studies.

CONDITIONS

Official Title

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Who Can Participate

Age: 60Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants who were enrolled and received treatment with JNJ-81201887 or sham in a parent clinical study (81201887MDG2001, 81201887MDG1003)
  • Females (women of childbearing potential), male participants, and partners of male participants will not be required to use contraception in this LTE study
  • Must sign an informed consent form (ICF) indicating that participant understands the purpose of, and procedures required for, the study and is willing to participate in the study. The ICF may be signed by an impartial witness and/or legally designated representative depending on national/local regulations
Not Eligible

You will not qualify if you...

  • There are no exclusion criteria for this LTE study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 104 locations

1

Retina Associates Southwest PC

Tucson, Arizona, United States, 85704

Actively Recruiting

2

Retina Consultants of Orange County

Fullerton, California, United States, 92835

Actively Recruiting

3

Shiley Eye Institute Jacobs Retina Center

La Jolla, California, United States, 92093 0946

Actively Recruiting

4

California Retina Consultants

Oxnard, California, United States, 93036

Actively Recruiting

5

California Eye Medical Specialists

Pasadena, California, United States, 91107

Actively Recruiting

6

Retina Consultants San Diego

Poway, California, United States, 92064

Actively Recruiting

7

Bay Area Retina Associates

Walnut Creek, California, United States, 94598

Actively Recruiting

8

Retina Group of Florida

Fort Lauderdale, Florida, United States, 33308

Actively Recruiting

9

VitreoRetinal Associates, PA

Gainesville, Florida, United States, 32607

Actively Recruiting

10

Retina Specialty Institute

Pensacola, Florida, United States, 32503

Actively Recruiting

11

Retina Vitreous Associates of Florida

St. Petersburg, Florida, United States, 33711

Actively Recruiting

12

Georgia Retina

Marietta, Georgia, United States, 30060

Actively Recruiting

13

Marietta Eye Clinic

Marietta, Georgia, United States, 30060

Actively Recruiting

14

University Retina

Lemont, Illinois, United States, 60439

Actively Recruiting

15

Midwest Eye Institute

Carmel, Indiana, United States, 46032

Actively Recruiting

16

Maine Eye Center

Portland, Maine, United States, 04101

Actively Recruiting

17

Retina Specialists

Baltimore, Maryland, United States, 21204

Actively Recruiting

18

The Retina Group of Washington

Chevy Chase, Maryland, United States, 20815

Actively Recruiting

19

Cumberland Valley Retina Consultants

Hagerstown, Maryland, United States, 21740

Actively Recruiting

20

Ophthalmic Consultants of Boston

Boston, Massachusetts, United States, 02114

Actively Recruiting

21

Foundation for Vision Research

Grand Rapids, Michigan, United States, 49546

Actively Recruiting

22

Retina Consultants of Minnesota

Saint Louis Park, Minnesota, United States, 55416

Actively Recruiting

23

The Retina Institute

St Louis, Missouri, United States, 63128

Actively Recruiting

24

Sierra Eye Associates

Reno, Nevada, United States, 89502

Actively Recruiting

25

Retina-Vitreous Surgeons of Central New York

Liverpool, New York, United States, 13088

Actively Recruiting

26

Asheville Eye Associates - Western Carolina Retinal Associates

Asheville, North Carolina, United States, 28803

Actively Recruiting

27

Duke Eye Center

Durham, North Carolina, United States, 27705

Actively Recruiting

28

Graystone Eye

Hickory, North Carolina, United States, 28602

Actively Recruiting

29

NC Retina Associates

Wake Forest, North Carolina, United States, 27587

Actively Recruiting

30

Cincinnati Eye Institute

Cincinnati, Ohio, United States, 45242

Actively Recruiting

31

Cleveland Clinic Main Campus

Cleveland, Ohio, United States, 44195

Actively Recruiting

32

Verum Research LLC

Eugene, Oregon, United States, 97401

Actively Recruiting

33

Cascade Medical Research Institute, LLC

Springfield, Oregon, United States, 97477

Actively Recruiting

34

Erie Retina Research

Erie, Pennsylvania, United States, 16505

Actively Recruiting

35

Charleston Neuroscience Institute, LLC

Beaufort, South Carolina, United States, 29902

Actively Recruiting

36

Austin Clinical Research

Austin, Texas, United States, 78750

Actively Recruiting

37

Texas Retina Associates

Dallas, Texas, United States, 75231

Actively Recruiting

38

UT Southwestern Medical Center

Dallas, Texas, United States, 75390

Actively Recruiting

39

Retina Associates Of South Texas P A

San Antonio, Texas, United States, 78240

Actively Recruiting

40

Retina Consultants of Texas

The Woodlands, Texas, United States, 77384

Actively Recruiting

41

Strategic Clinical Research Group

Willow Park, Texas, United States, 76087

Actively Recruiting

42

University of Utah

Salt Lake City, Utah, United States, 84132

Actively Recruiting

43

Piedmont Eye Center

Lynchburg, Virginia, United States, 24502

Actively Recruiting

44

Wagner Kapoor Research institute

Norfolk, Virginia, United States, 23502

Actively Recruiting

45

Spokane Eye Clinical Research

Spokane, Washington, United States, 99204

Actively Recruiting

46

Centre for Eye Research Australia

East Melbourne, Australia, 3002

Actively Recruiting

47

Strathfield Retina Clinic

Strathfield, Australia, 2135

Actively Recruiting

48

Sydney Retina Clinic and Day Surgery

Sydney, Australia, 2000

Actively Recruiting

49

Sydney West Retina

Westmead, Australia, 2145

Actively Recruiting

50

Ziekenhuis Oost-Limburg

Genk, Belgium, 3600

Actively Recruiting

51

UZ Gent

Ghent, Belgium, 9000

Actively Recruiting

52

UZ Leuven Gasthuisberg

Leuven, Belgium, 3000

Actively Recruiting

53

Alberta Retina Consultants

Edmonton, Alberta, Canada, T5H 0X5

Actively Recruiting

54

Beijing Tongren Hospital CMU

Beijing, China, 100730

Actively Recruiting

55

West China Hospital Si Chuan University

Chengdu, China, 610041

Actively Recruiting

56

Shanghai General Hospital

Shanghai, China, 200080

Actively Recruiting

57

Fakultni nemocnice Kralovske Vinohrady

Prague, Czechia, 100 34

Actively Recruiting

58

AXON Clinical s.r.o.

Prague, Czechia, 15000

Actively Recruiting

59

University Hospital Of Copenhagen, Glostrup Hospital

Glostrup Municipality, Denmark, 2600

Active, Not Recruiting

60

Universitaets-Augenklinik Bonn

Bonn, Germany, 53127

Actively Recruiting

61

Klinikum Gottingen der Georg August Universitat

Göttingen, Germany, 37075

Actively Recruiting

62

Medizinische Hochschule Hannover

Hanover, Germany, 30625

Actively Recruiting

63

Universitaetsklinikum Leipzig

Leipzig, Germany, 04103

Actively Recruiting

64

Klinikum Ludwigshafen

Ludwigshafen am Rhein, Germany, 67063

Actively Recruiting

65

Augenzentrum am St Franziskus Hospital Munster

Münster, Germany, 48145

Actively Recruiting

66

Universitaetsklinikum Tuebingen

Tübingen, Germany, 72076

Actively Recruiting

67

Eszak Pesti Centrumkorhaz Honvedkorhaz

Budapest, Hungary, 1062

Actively Recruiting

68

Ganglion Orvosi Központ

Pécs, Hungary, 7621

Actively Recruiting

69

Zala Varmegyei Szent Rafael Korhaz

Zalaegerszeg, Hungary, 8900

Actively Recruiting

70

Azienda Ospedaliero Universitaria di Ferrara

Ferrara, Italy, 44124

Actively Recruiting

71

ASST Fatebenefratelli Sacco

Milan, Italy, 20157

Actively Recruiting

72

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

Milan, Italy, 20122

Actively Recruiting

73

IRCCS Ospedale San Raffaele

Milan, Italy, 20132

Actively Recruiting

74

Azienda Ospedaliero Universitaria Luigi Vanvitelli

Naples, Italy, 80138

Actively Recruiting

75

Fondazione Policlinico Universitario A Gemelli IRCCS

Roma, Italy, 00168

Actively Recruiting

76

Radboudumc

Nijmegen, Netherlands, 6525 GA

Actively Recruiting

77

Het Oogziekenhuis Rotterdam

Rotterdam, Netherlands, 3011

Actively Recruiting

78

Oftalmika

Bydgoszcz, Poland, 85 631

Active, Not Recruiting

79

Warszawski Szpital Okulistyczny

Warsaw, Poland, 01 258

Active, Not Recruiting

80

Uls Coimbra - Hosp. Univ. Coimbra

Coimbra, Portugal, 3000 075

Active, Not Recruiting

81

Espaco Medico de Coimbra

Coimbra, Portugal, 3030 163

Active, Not Recruiting

82

Uls Sao Joao

Porto, Portugal, 4200 319

Actively Recruiting

83

Centro de Oftalmologia Barraquer

Barcelona, Spain, 08021

Actively Recruiting

84

Centro Medico Teknon S.L.

Barcelona, Spain, 08022

Actively Recruiting

85

Inst. Cat. de Retina

Barcelona, Spain, 08022

Actively Recruiting

86

Clinica Oftalvist Valencia

Burjassot, Spain, 46100

Actively Recruiting

87

Hosp. La Arruzafa

Córdoba, Spain, 14012

Actively Recruiting

88

Hosp Univ Fund Jimenez Diaz

Madrid, Spain, 28040

Actively Recruiting

89

Hosp. Univ. 12 de Octubre

Madrid, Spain, 28041

Actively Recruiting

90

Clinica Baviera Madrid Castellana

Madrid, Spain, 28046

Actively Recruiting

91

Hosp. Univ. Pta. de Hierro Majadahonda

Majadahonda, Spain, 28222

Actively Recruiting

92

Clinica Univ. de Navarra

Pamplona, Spain, 31008

Actively Recruiting

93

Idc Salud Hosp. Gral. de Catalunya

Sant Cugat del Vallès, Spain, 08195

Actively Recruiting

94

Hosp. Virgen Del Rocio

Seville, Spain, 41013

Actively Recruiting

95

Hosp. Clinico Univ. Lozano Blesa

Zaragoza, Spain, 50009

Actively Recruiting

96

S:t Eriks Ogonsjukhus

Stockholm, Sweden, 171 64

Active, Not Recruiting

97

Inselspital Universitatsspital Bern

Bern, Switzerland, 3010

Actively Recruiting

98

Hacettepe University Medical Faculty

Ankara, Turkey (Türkiye), 06230

Actively Recruiting

99

Baskent University Ankara Hospital

Ankara, Turkey (Türkiye), 06490

Actively Recruiting

100

Dokuz Eylul University Medical Faculty

Izmir, Turkey (Türkiye), 35330

Actively Recruiting

101

Bristol Eye Hospital

Bristol, United Kingdom, BS1 2LX

Active, Not Recruiting

102

Oxford Eye Hospital

Headington, United Kingdom, OX3 9DU

Active, Not Recruiting

103

The Retina Clinic London

London, United Kingdom, W1G 9AX

Active, Not Recruiting

104

Royal Victoria Infirmary

Newcastle upon Tyne, United Kingdom, NE1 4LP

Active, Not Recruiting

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Research Team

S

Study Contact

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) | DecenTrialz