Actively Recruiting
Long-term Extension Study of JNJ-81201887 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Led by Janssen Research & Development, LLC · Updated on 2026-06-05
274
Participants Needed
104
Research Sites
46 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to assess the long-term safety and tolerability of JNJ-81201887, a medicine given by injection into the eye, in people with geographic atrophy secondary to age-related macular degeneration. The study includes participants who were previously treated in earlier clinical studies of this medicine. The main goal is to monitor any eye or systemic side effects and abnormal findings over up to five years. Participants who received low or high doses of JNJ-81201887 in earlier studies, as well as those initially given a sham procedure who may have later received the medicine, will join this extension study. No new treatments or injections will be given during this long-term study. It is designed as a randomized, triple-masked phase 2 trial to carefully observe participants over time. During the study, participants will have regular eye examinations, retinal imaging, and laboratory tests to check for any changes or adverse events related to the earlier treatment. Researchers will track ocular and systemic treatment-emergent adverse events for up to five years. Participants will be involved throughout this period with scheduled visits to monitor their condition and safety status consistently.
CONDITIONS
Brief Title
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants who were enrolled and received treatment with JNJ-81201887 or sham in a parent clinical study (81201887MDG2001, 81201887MDG1003)
- Females (women of childbearing potential), male participants, and partners of male participants are not required to use contraception in this LTE study
- Must sign an informed consent form indicating understanding of the study purpose and willingness to participate
You will not qualify if you...
- There are no exclusion criteria for this long-term extension study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants are monitored over time without receiving additional study intervention, with assessments of ocular and systemic safety.
Periodic visits for assessments including clinical laboratory tests, retinal imaging, and eye examinations
Trial Site Locations
Total: 104 locations
1
Retina Associates Southwest PC
Tucson, Arizona, United States, 85704
Actively Recruiting
2
Retina Consultants of Orange County
Fullerton, California, United States, 92835
Actively Recruiting
3
Shiley Eye Institute Jacobs Retina Center
La Jolla, California, United States, 92093 0946
Actively Recruiting
4
California Retina Consultants
Oxnard, California, United States, 93036
Actively Recruiting
5
California Eye Medical Specialists
Pasadena, California, United States, 91107
Actively Recruiting
6
Retina Consultants San Diego
Poway, California, United States, 92064
Actively Recruiting
7
Bay Area Retina Associates
Walnut Creek, California, United States, 94598
Actively Recruiting
8
Retina Group of Florida
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
9
VitreoRetinal Associates, PA
Gainesville, Florida, United States, 32607
Actively Recruiting
10
Retina Specialty Institute
Pensacola, Florida, United States, 32503
Actively Recruiting
11
Retina Vitreous Associates of Florida
St. Petersburg, Florida, United States, 33711
Actively Recruiting
12
Georgia Retina
Marietta, Georgia, United States, 30060
Actively Recruiting
13
Marietta Eye Clinic
Marietta, Georgia, United States, 30060
Actively Recruiting
14
University Retina
Lemont, Illinois, United States, 60439
Actively Recruiting
15
Midwest Eye Institute
Carmel, Indiana, United States, 46032
Actively Recruiting
16
Maine Eye Center
Portland, Maine, United States, 04101
Actively Recruiting
17
Retina Specialists
Baltimore, Maryland, United States, 21204
Actively Recruiting
18
The Retina Group of Washington
Chevy Chase, Maryland, United States, 20815
Actively Recruiting
19
Cumberland Valley Retina Consultants
Hagerstown, Maryland, United States, 21740
Actively Recruiting
20
Ophthalmic Consultants of Boston
Boston, Massachusetts, United States, 02114
Actively Recruiting
21
Foundation for Vision Research
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
22
Retina Consultants of Minnesota
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
23
The Retina Institute
St Louis, Missouri, United States, 63128
Actively Recruiting
24
Sierra Eye Associates
Reno, Nevada, United States, 89502
Actively Recruiting
25
Retina-Vitreous Surgeons of Central New York
Liverpool, New York, United States, 13088
Actively Recruiting
26
Asheville Eye Associates - Western Carolina Retinal Associates
Asheville, North Carolina, United States, 28803
Actively Recruiting
27
Duke Eye Center
Durham, North Carolina, United States, 27705
Actively Recruiting
28
Graystone Eye
Hickory, North Carolina, United States, 28602
Actively Recruiting
29
NC Retina Associates
Wake Forest, North Carolina, United States, 27587
Actively Recruiting
30
Cincinnati Eye Institute
Cincinnati, Ohio, United States, 45242
Actively Recruiting
31
Cleveland Clinic Main Campus
Cleveland, Ohio, United States, 44195
Actively Recruiting
32
Verum Research LLC
Eugene, Oregon, United States, 97401
Actively Recruiting
33
Cascade Medical Research Institute, LLC
Springfield, Oregon, United States, 97477
Actively Recruiting
34
Erie Retina Research
Erie, Pennsylvania, United States, 16505
Actively Recruiting
35
Charleston Neuroscience Institute, LLC
Beaufort, South Carolina, United States, 29902
Actively Recruiting
36
Austin Clinical Research
Austin, Texas, United States, 78750
Actively Recruiting
37
Texas Retina Associates
Dallas, Texas, United States, 75231
Actively Recruiting
38
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
39
Retina Associates Of South Texas P A
San Antonio, Texas, United States, 78240
Actively Recruiting
40
Retina Consultants of Texas
The Woodlands, Texas, United States, 77384
Actively Recruiting
41
Strategic Clinical Research Group
Willow Park, Texas, United States, 76087
Actively Recruiting
42
University of Utah
Salt Lake City, Utah, United States, 84132
Actively Recruiting
43
Piedmont Eye Center
Lynchburg, Virginia, United States, 24502
Actively Recruiting
44
Wagner Kapoor Research institute
Norfolk, Virginia, United States, 23502
Actively Recruiting
45
Spokane Eye Clinical Research
Spokane, Washington, United States, 99204
Actively Recruiting
46
Centre for Eye Research Australia
East Melbourne, Australia, 3002
Actively Recruiting
47
Strathfield Retina Clinic
Strathfield, Australia, 2135
Actively Recruiting
48
Sydney Retina Clinic and Day Surgery
Sydney, Australia, 2000
Actively Recruiting
49
Sydney West Retina
Westmead, Australia, 2145
Actively Recruiting
50
Ziekenhuis Oost-Limburg
Genk, Belgium, 3600
Active, Not Recruiting
51
UZ Gent
Ghent, Belgium, 9000
Active, Not Recruiting
52
UZ Leuven Gasthuisberg
Leuven, Belgium, 3000
Active, Not Recruiting
53
Alberta Retina Consultants
Edmonton, Alberta, Canada, T5H 0X5
Actively Recruiting
54
Beijing Tongren Hospital CMU
Beijing, China, 100730
Actively Recruiting
55
West China Hospital Si Chuan University
Chengdu, China, 610041
Actively Recruiting
56
Shanghai General Hospital
Shanghai, China, 200080
Actively Recruiting
57
Fakultni nemocnice Kralovske Vinohrady
Prague, Czechia, 100 34
Actively Recruiting
58
AXON Clinical s.r.o.
Prague, Czechia, 15000
Actively Recruiting
59
University Hospital Of Copenhagen, Glostrup Hospital
Glostrup Municipality, Denmark, 2600
Active, Not Recruiting
60
Universitaets-Augenklinik Bonn
Bonn, Germany, 53127
Actively Recruiting
61
Klinikum Gottingen der Georg August Universitat
Göttingen, Germany, 37075
Actively Recruiting
62
Medizinische Hochschule Hannover
Hanover, Germany, 30625
Actively Recruiting
63
Universitaetsklinikum Leipzig
Leipzig, Germany, 04103
Actively Recruiting
64
Klinikum Ludwigshafen
Ludwigshafen am Rhein, Germany, 67063
Actively Recruiting
65
Augenzentrum am St Franziskus Hospital Munster
Münster, Germany, 48145
Actively Recruiting
66
Universitaetsklinikum Tuebingen
Tübingen, Germany, 72076
Actively Recruiting
67
Eszak Pesti Centrumkorhaz Honvedkorhaz
Budapest, Hungary, 1062
Actively Recruiting
68
Ganglion Orvosi Központ
Pécs, Hungary, 7621
Actively Recruiting
69
Zala Varmegyei Szent Rafael Korhaz
Zalaegerszeg, Hungary, 8900
Actively Recruiting
70
Azienda Ospedaliero Universitaria di Ferrara
Ferrara, Italy, 44124
Actively Recruiting
71
ASST Fatebenefratelli Sacco
Milan, Italy, 20157
Actively Recruiting
72
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122
Actively Recruiting
73
IRCCS Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
74
Azienda Ospedaliero Universitaria Luigi Vanvitelli
Naples, Italy, 80138
Actively Recruiting
75
Fondazione Policlinico Universitario A Gemelli IRCCS
Roma, Italy, 00168
Actively Recruiting
76
Radboudumc
Nijmegen, Netherlands, 6525 GA
Active, Not Recruiting
77
Het Oogziekenhuis Rotterdam
Rotterdam, Netherlands, 3011
Active, Not Recruiting
78
Oftalmika
Bydgoszcz, Poland, 85 631
Active, Not Recruiting
79
Warszawski Szpital Okulistyczny
Warsaw, Poland, 01 258
Active, Not Recruiting
80
Uls Coimbra - Hosp. Univ. Coimbra
Coimbra, Portugal, 3000 075
Active, Not Recruiting
81
Espaco Medico de Coimbra
Coimbra, Portugal, 3030 163
Active, Not Recruiting
82
Uls Sao Joao
Porto, Portugal, 4200 319
Actively Recruiting
83
Centro de Oftalmologia Barraquer
Barcelona, Spain, 08021
Actively Recruiting
84
Centro Medico Teknon S.L.
Barcelona, Spain, 08022
Actively Recruiting
85
Inst. Cat. de Retina
Barcelona, Spain, 08022
Actively Recruiting
86
Clinica Oftalvist Valencia
Burjassot, Spain, 46100
Actively Recruiting
87
Hosp. La Arruzafa
Córdoba, Spain, 14012
Actively Recruiting
88
Hosp Univ Fund Jimenez Diaz
Madrid, Spain, 28040
Actively Recruiting
89
Hosp. Univ. 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
90
Clinica Baviera Madrid Castellana
Madrid, Spain, 28046
Actively Recruiting
91
Hosp. Univ. Pta. de Hierro Majadahonda
Majadahonda, Spain, 28222
Actively Recruiting
92
Clinica Univ. de Navarra
Pamplona, Spain, 31008
Actively Recruiting
93
Idc Salud Hosp. Gral. de Catalunya
Sant Cugat del Vallès, Spain, 08195
Actively Recruiting
94
Hosp. Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
95
Hosp. Clinico Univ. Lozano Blesa
Zaragoza, Spain, 50009
Actively Recruiting
96
S:t Eriks Ogonsjukhus
Stockholm, Sweden, 171 64
Active, Not Recruiting
97
Inselspital Universitatsspital Bern
Bern, Switzerland, 3010
Actively Recruiting
98
Hacettepe University Medical Faculty
Ankara, Turkey (Türkiye), 06230
Actively Recruiting
99
Baskent University Ankara Hospital
Ankara, Turkey (Türkiye), 06490
Actively Recruiting
100
Dokuz Eylul University Medical Faculty
Izmir, Turkey (Türkiye), 35330
Actively Recruiting
101
Bristol Eye Hospital
Bristol, United Kingdom, BS1 2LX
Active, Not Recruiting
102
Oxford Eye Hospital
Headington, United Kingdom, OX3 9DU
Active, Not Recruiting
103
The Retina Clinic London
London, United Kingdom, W1G 9AX
Active, Not Recruiting
104
Royal Victoria Infirmary
Newcastle upon Tyne, United Kingdom, NE1 4LP
Active, Not Recruiting
Research Team
S
Study Contact
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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