Actively Recruiting
A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Led by Centessa Pharmaceuticals (UK) Limited · Updated on 2026-04-16
90
Participants Needed
24
Research Sites
37 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a long-term extension (LTE) of the parent Study ORX750 0201, and will provide long-term open-label safety, tolerability, and efficacy of ORX750 in participants with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH).
CONDITIONS
Official Title
A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of narcolepsy type 1, narcolepsy type 2, or idiopathic hypersomnia
- Completed the full treatment period in the parent study ORX750-0201 (CRYSTAL-1)
- Willing and able to follow additional study requirements
You will not qualify if you...
- Development of any new disease or disorder that prevents continued participation
- Unable to stop excluded medications, including those for narcolepsy or idiopathic hypersomnia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
Auburn, alabama
Auburn, Alabama, United States, 36832
Actively Recruiting
2
Santa Ana, California
Santa Ana, California, United States, 92705
Actively Recruiting
3
Miami, Florida
Miami, Florida, United States, 33176
Actively Recruiting
4
Orlando, Florida
Orlando, Florida, United States, 32807
Actively Recruiting
5
Winter Park, FL
Winter Park, Florida, United States, 32789
Actively Recruiting
6
Stockbridge, GA
Atlanta, Georgia, United States, 30281
Actively Recruiting
7
Atlanta, Georgia
Atlanta, Georgia, United States, 30328
Actively Recruiting
8
Sterling Heights, Michigan
Sterling Heights, Michigan, United States, 48314
Actively Recruiting
9
Hendersen, Navada
Henderson, Nevada, United States, 89052
Actively Recruiting
10
Henderson, Nevada
Henderson, Nevada, United States, 89052
Actively Recruiting
11
Denver, North Carolina
Denver, North Carolina, United States, 28037
Actively Recruiting
12
Huntersville, North Carolina
Huntersville, North Carolina, United States, 28070
Actively Recruiting
13
Cincinnati, Ohio
Cincinnati, Ohio, United States, 45245
Actively Recruiting
14
Dublin
Dublin, Ohio, United States, 43017
Actively Recruiting
15
Abington, Pennsylvania
Abington, Pennsylvania, United States, 19046
Actively Recruiting
16
Willow Grove, Pennsylvania
Willow Grove, Pennsylvania, United States, 19090
Actively Recruiting
17
North Charleston, South Carolina
North Charleston, South Carolina, United States, 29406-9196
Actively Recruiting
18
Austin, Texas
Austin, Texas, United States, 30328
Actively Recruiting
19
El Paso, Texas
El Paso, Texas, United States, 79912
Actively Recruiting
20
Toronto
Toronto, Ontario, Canada, M5S 3A3
Actively Recruiting
21
Bologna
Bologna, BO, Italy, 40139
Actively Recruiting
22
Verona
Verona, VR, Italy, 37134
Actively Recruiting
23
Móstoles, Madrid
Móstoles, Madrid, Spain, 28938
Actively Recruiting
24
Álava, Spain
Álava, Spain, 01004
Actively Recruiting
Research Team
O
Orexin Centessa Program Lead
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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